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首页> 外文期刊>Journal of assisted reproduction and genetics >Timing and duration of use of GnRH antagonist down-regulation for IVF/ICSI cycles have no impact on oocyte quality or pregnancy outcomes.
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Timing and duration of use of GnRH antagonist down-regulation for IVF/ICSI cycles have no impact on oocyte quality or pregnancy outcomes.

机译：在IVF / ICSI周期中GnRH拮抗剂下调的时机和持续时间对卵母细胞质量或妊娠结局没有影响。

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摘要

PURPOSE: To evaluate whether oocyte quality, implantation and pregnancy outcomes in in vitro fertilization (IVF)/intra-cytoplasmic sperm injection (ICSI) are related to the duration of gonadotropin-releasing hormone (GnRH)-antagonist use or the timing of its initiation. METHODS: Retrospective cohort study of 178 conventional IVF/ICSI cycles. All patients underwent ovarian stimulation with gonadotropins and GnRH-antagonist for pituitary down-regulation. Spearman correlations and logistic regression were used for statistical analysis. RESULTS: There was no correlation between the duration of use or the timing of initiation of GnRH-antagonist with oocyte quality or implantation and pregnancy outcomes. Oocyte quality was influenced by the peak estradiol. Implantation was influenced by the patient's age. Early pregnancy loss, by the endometrial thickness on human chorionic gonadotropin-day. Ongoing pregnancy was independent from the variables evaluated. CONCLUSIONS: GnRH-antagonist duration of use or starting day did not influence oocyte quality, implantation rates, and pregnancy rates. We hypothesize that a follicle stimulating hormone/luteinizing hormone dose increase when antagonist was started, may have had an impact on our findings.
机译：目的：评估体外受精（IVF）/胞浆内精子注射（ICSI）的卵母细胞质量，植入和妊娠结局是否与促性腺激素释放激素（GnRH）-拮抗剂的使用时间或起始时间有关。方法：对178个常规IVF / ICSI周期进行回顾性队列研究。所有患者均接受促性腺激素和GnRH拮抗剂对卵巢的刺激以垂体下调。 Spearman相关性和逻辑回归用于统计分析。结果：GnRH拮抗剂的使用时间或开始时间与卵母细胞的质量或着床与妊娠结局之间没有相关性。卵母细胞的质量受雌二醇峰值的影响。植入受患者年龄的影响。早孕流失者，通过子宫内膜厚度对人绒毛膜促性腺激素的天数。持续妊娠独立于所评估的变量。结论：GnRH-拮抗剂的使用期限或起始日不影响卵母细胞质量，着床率和妊娠率。我们假设开始拮抗剂时卵泡刺激素/促黄体生成激素的剂量增加可能对我们的发现有影响。

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