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首页> 外文期刊>Journal of biochemical and molecular toxicology >p-Aminophenol-induced hepatotoxicity in hamsters: Role of glutathione.
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p-Aminophenol-induced hepatotoxicity in hamsters: Role of glutathione.

机译：对氨基苯酚诱导的仓鼠肝毒性：谷胱甘肽的作用。

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p-Aminophenol (PAP) is a widely used industrial chemical and a known nephrotoxin. Recently, it was found to also cause hepatotoxicity and glutathione (GSH) depletion in mice. The exact mechanism of liver toxicity is not known. The aims of this study were to determine whether PAP can cause acute hepatotoxicity in hamsters and to further investigate the role of GSH in PAP-induced toxicity. PAP was administered ip to hamsters in doses of 200-800 mg/kg. Liver damage at 24 h after PAP administration was assessed by elevations in plasma enzyme activities and histopathologic examination. GSH and cysteine (Cys) levels in liver at 4 h were determined by HPLC. PAP decreased hepatic GSH concentration to 8% and Cys to 30% of vehicle control values. It increased plasma glutamic pyruvic transaminase (GPT) activity by 47-fold and sorbitol dehydrogenase (SDH) activity by 113-fold. PAP also caused severe centrilobular hepatocellular necrosis. 2(RS)-n-Propylthiazolidine-4(R)-carboxylic acid (PTCA), a Cys precursor, attenuated the PAP-induced decreases in hepatic sulfhydryl levels; GSH and Cys were 39% and 78% of vehicle controls, respectively. PTCA also attenuated the PAP-induced elevations in plasma enzyme activities and hepatic necrosis. It was concluded that PAP hepatotoxicity is associated with depletion of hepatic GSH and can be prevented by PTCA.
机译：对氨基苯酚（PAP）是一种广泛使用的工业化学品，是一种已知的肾毒素。最近，发现它还引起小鼠的肝毒性和谷胱甘肽（GSH）消耗。肝毒性的确切机制尚不清楚。这项研究的目的是确定PAP是否可以引起仓鼠急性肝毒性，并进一步研究GSH在PAP诱导的毒性中的作用。以200-800 mg / kg的剂量将PAP腹腔内给药。通过血浆酶活性的升高和组织病理学检查评估PAP给药后24小时的肝损害。通过HPLC测定4小时时肝脏中的GSH和半胱氨酸（Cys）水平。 PAP将肝脏GSH浓度降低至媒介物对照值的8％，将Cys降低至媒介物对照值的30％。它使血浆谷氨酸丙酮酸转氨酶（GPT）活性增加47倍，而山梨糖醇脱氢酶（SDH）活性增加113倍。 PAP还引起严重的小叶肝细胞坏死。 Cys的前体2（RS）-正丙硫唑烷-4（R）-羧酸（PTCA）减弱了PAP诱导的肝巯基水平的降低; GSH和Cys分别为媒介物对照的39％和78％。 PTCA还减弱了PAP诱导的血浆酶活性和肝坏死升高。结论是，PAP的肝毒性与肝GSH的消耗有关，可以通过PTCA预防。

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