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首页> 外文期刊>Journal of biomaterials applications >Effect of cryoprotectant incubation time on handling properties of allogeneic tendons prepared for knee ligament reconstruction.
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Effect of cryoprotectant incubation time on handling properties of allogeneic tendons prepared for knee ligament reconstruction.

机译：防冻剂孵育时间对准备用于重建膝盖韧带的同种异体肌腱的处理性能的影响。

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摘要

Soft tissue tendon allografts prepared for anterior cruciate ligament reconstruction are becoming increasingly popular; although concerns exist regarding increased long-term laxity and traumatic rupture rates. This qualitative study evaluated the tissue handling properties of human tibialis posterior tendons prepared using a patented process to improve allograft remodeling and ligamentization under differing cryoprotectant incubation times over 60-min rehydration. Tendons that had been incubated for 8 h had smaller diameters than those that were incubated for 2 h (8.5 +/- 1.5 mm vs. 9.1 +/- 1.3 mm, p = 0.02). Qualitative tissue handling property results indicated that the 8-h incubation had a negative affect on tissue color. Both incubation time and rehydration time influenced tensile stiffness, compressive resilience, and ease of tissue handling for allograft preparation with the 8-h group displaying poorer results. This study concludes that an 8-h cryoprotectant incubation time is detrimental to qualitative allogeniec tibialis posterior tendon properties. Both groups tended to improve with longer rehydration times, however the 8-h incubation group remained actively dehydrated as evidenced by its smaller diameter and poorer tissue handling properties. Suboptimally rehydrated tendons would be more likely to accrue damage during allograft preparation or during implantation.
机译：为前交叉韧带重建准备的软组织腱同种异体移植正变得越来越普遍。尽管人们担心长期松弛和创伤性破裂发生率增加。这项定性研究评估了使用专利工艺制备的人胫骨后肌腱的组织处理性能，该工艺可在不同的防冻剂孵育时间超过60分钟的补液时间下改善同种异体移植物的重塑和韧带化。孵育8小时的肌腱的直径小于孵育2小时的肌腱的直径（8.5 +/- 1.5毫米vs. 9.1 +/- 1.3毫米，p = 0.02）。定性的组织处理性能结果表明，孵育8小时对组织颜色有负面影响。孵育时间和补液时间都会影响同种异体移植物的拉伸刚度，压缩弹性和组织处理的便利性，而8h组显示的结果较差。这项研究得出的结论是，冷冻保护剂的8小时保温时间不利于定性同种异体胫骨后肌腱的特性。两组都倾向于通过更长的补液时间来改善，但是8小时孵育组仍然保持主动脱水，这是由其较小的直径和较差的组织处理性能所证明的。次优复水的肌腱在同种异体移植准备过程或植入过程中更有可能产生损伤。

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