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首页> 外文期刊>Journal of Biomechanics >Bioinjection treatment: Effects of post-injection residual stress on left ventricular wall stress
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Bioinjection treatment: Effects of post-injection residual stress on left ventricular wall stress

机译：生物注射治疗：注射后残余应力对左心室壁应力的影响

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摘要

Injection of biomaterials into diseased myocardium has been associated with decreased myofiber stress, restored left ventricular (LV) geometry and improved LV function. However, its exact mechanism(s) of action remained unclear. In this work, we present the first patient-specific computational model of biomaterial injection that accounts for the possibility of residual strain and stress introduced by this treatment. We show that the presence of residual stress can create more heterogeneous regional myofiber stress and strain fields. Our simulation results show that the treatment generates low stress and stretch areas between injection sites, and high stress and stretch areas between the injections and both the endocardium and epicardium. Globally, these local changes are translated into an increase in average myofiber stress and its standard deviation (from 6.9±4.6 to 11.2±48.8. kPa and 30±15 to 35.1±50.9. kPa at end-diastole and end-systole, respectively). We also show that the myofiber stress field is sensitive to the void-to-size ratio. For a constant void size, the myofiber stress field became less heterogeneous with decreasing injection volume. These results suggest that the residual stress and strain possibly generated by biomaterial injection treatment can have large effects on the regional myocardial stress and strain fields, which may be important in the remodeling process.
机译：将生物材料注入患病的心肌与降低肌纤维压力，恢复左心室（LV）几何形状和改善LV功能有关。但是，其确切的作用机制仍不清楚。在这项工作中，我们介绍了第一个针对患者的生物材料注射计算模型，该模型考虑了这种治疗方法引入的残余应变和应力的可能性。我们表明，残余应力的存在可以创建更多不均匀的区域肌纤维应力和应变场。我们的模拟结果表明，该处理在注射部位之间产生低应力和拉伸区域，在注射之间以及内膜和心外膜之间产生高应力和拉伸区域。在全球范围内，这些局部变化转化为平均肌纤维应力和其标准偏差的增加（舒张末期和收缩期末分别从6.9±4.6到11.2±48.8。kPa和30±15到35.1±50.9。kPa）。 。我们还表明，肌纤维应力场对空洞与尺寸之比敏感。对于恒定的空隙尺寸，随着注射量的减少，肌纤维应力场变得越来越不均匀。这些结果表明，生物材料注射处理可能产生的残余应力和应变可能对局部心肌应力和应变场产生很大影响，这可能在重塑过程中很重要。

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