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首页> 外文期刊>Journal of Biomechanics >Evaluation of a Hill based muscle model for the energy cost and efficiency of muscular contraction.
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Evaluation of a Hill based muscle model for the energy cost and efficiency of muscular contraction.

机译：评估基于希尔的肌肉模型的能量消耗和肌肉收缩效率。

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The purpose of this study was to evaluate a Hill-based mathematical model of muscle energetics and to disclose inconsistencies in existing experimental data. For this purpose, we simulated iso-velocity contractions of mouse fast twitch EDL and slow twitch SOL fibers, and we compared the outcome to experimental results. The experimental results were extracted from two studies published in the literature, which were based on the same methodology but yielded different outcomes (B96 and B93). In the model, energy cost was modeled as the sum of heat and work. Parameters used to model heat rate were entirely independent of the experimental data-sets. Parameters describing the mechanical behavior were derived from both experimental studies. The model was found to accurately predict the muscle energetics and mechanical efficiency of data-set B96. The model could not, however, replicate the energetics and efficiency of SOL and EDL that were found in data-set B93. The model overestimated the shortening heat rateof EDL but, surprisingly, also the mechanical work rate for both muscles. This was surprising since mechanical characteristics of the model were derived directly from the experimental data. It was demonstrated that the inconsistencies in data-set B93 must have been due to some unexplained confounding artifact. It was concluded that the presented model of muscle energetics is valid for iso-velocity contractions of mammalian muscle since it accurately predicts experimental results of an independent data-set (B96). In addition, the model appeared to be helpful in revealing inconsistencies in a second data-set (B93).
机译：这项研究的目的是评估基于希尔的肌肉能量学数学模型，并揭示现有实验数据中的矛盾之处。为此，我们模拟了小鼠快速抽搐EDL和慢速抽搐SOL纤维的等速收缩，并将结果与​​实验结果进行了比较。实验结果是从文献中发表的两项研究中提取的，这些研究基于相同的方法，但得出的结果不同（B96和B93）。在模型中，能源成本被建模为热量和功的总和。用于模拟热速率的参数完全独立于实验数据集。描述机械行为的参数来自两个实验研究。发现该模型可以准确预测数据集B96的肌肉能量和机械效率。但是，该模型无法复制在数据集B93中发现的SOL和EDL的能量和效率。该模型高估了EDL缩短的热效率，但出乎意料的是，高估了两条肌肉的机械工作效率。这是令人惊讶的，因为模型的机械特性直接来自实验数据。事实证明，数据集B93中的不一致一定是由于一些无法解释的混淆工件造成的。结论是，提出的肌肉能量学模型对于哺乳动物肌肉的等速收缩是有效的，因为它可以准确地预测独立数据集的实验结果（B96）。此外，该模型似乎有助于揭示第二个数据集中的不一致性（B93）。

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