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The material properties of the native porcine mitral valve chordae tendineae: an in vitro investigation.

机译:天然猪二尖瓣腱索肌腱的材料特性:体外研究。

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The material properties of the mitral valve chordae tendineae are important for the understanding of leaflet coaptation configuration and chordal pathology. There is limited information about the mechanical properties of the chordae during physiologic loading. Dual camera stereo photogrammetry was used to measure strains of the chordae in vitro under physiologic loading conditions. Two high-speed, high-resolution cameras captured the movement of graphite markers attached to the central section of the chordae. A uniaxial test simulating the same loading conditions was conducted on the same chordae using the same markers. The maximum strain experienced during the cardiac cycle was 4.29% +/- 3.43%. The loading rate was higher at 75.3% +/- 48.6% strain per second than the unloading rate at -54.8% +/- -56.6% strain per second. The anterior lateral strut chordae had a higher maximum strain (5.7% +/- 3.8%) and loading rate (80.5% +/- 51.9% strain per second) than the posterior medial strut chordae (5.5% +/- 2.3% strain and 68.1% +/- 48.3% strain per second). The posterior medial strut chordae had a higher unloading rate (-68.5% +/- -59.1% strain per second) than the anterior lateral strut chordae (-44.9% +/- -57.2% strain per second). Although the anterior lateral and posterior medial strut chordae have a significantly different diameter and length, they experience a similar strain, strain rate, and tension. In conclusion, a non-destructive technique was developed to measure in vitro chordal strain in the mitral valve. This technique allows the investigation of the behavior of biological tissues under physiologic loading conditions.
机译:二尖瓣腱索肌腱的材料特性对于理解小叶接合构型和腱索病理非常重要。关于在生理负荷期间腱索的机械性质的信息有限。双摄像头立体摄影测量法用于在生理负荷条件下体外测量腱索的应变。两个高速,高分辨率相机捕获了附着在腱索中央部分的石墨标记的运动。使用相同的标记在相同的弦上进行了模拟相同加载条件的单轴测试。在心动周期中经历的最大应变为4.29%+/- 3.43%。每秒75.3%+/- 48.6%应变时的加载速率高于每秒-54.8%+/- -56.6%应变时的卸载速率。前外侧支撑腱索的最大应变(5.7%+/- 3.8%应变)和负荷率(每秒80.5%+/- 51.9%应变)比后内侧支撑腱索(5.5%+/- 2.3%应变和每秒68.1%+/- 48.3%的应变)。后内侧支撑腱索的卸载速率(-68.5%+/- -59.1%应变/秒)比前外侧支撑腱索(-44.9%+/- -57.2%应变/秒)更高。尽管前外侧和后内侧支撑腱索的直径和长度明显不同,但它们承受的应变,应变率和张力相似。总之,开发了一种非破坏性技术来测量二尖瓣的体外弦张力。该技术允许研究在生理负荷条件下生物组织的行为。

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