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首页> 外文期刊>Journal of Biomechanics >A new imaging technique to study 3-D plaque and shear stress distribution in human coronary artery bifurcations in vivo.
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A new imaging technique to study 3-D plaque and shear stress distribution in human coronary artery bifurcations in vivo.

机译：一种研究人体冠状动脉分叉体内3-D斑块和切应力分布的新成像技术。

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OBJECTIVE: Bifurcations of coronary arteries are predilection sites for atherosclerosis and expansive remodeling, the latter being associated with plaque vulnerability. Both are related to blood flow-induced shear stress (SS). We present a new approach to generate 3-D reconstructions of coronary artery bifurcations in vivo and investigate the relationship between SS, wall thickness (WT) and remodeling. METHODS: The patient specific 3-D reconstruction of the main branch of the bifurcation was obtained by combining intravascular ultrasound and biplane angiography, and the 3-D lumen of the side branch was based on biplane angiography only. The two data sets were fused and computational methods were applied to determine the SS distribution, using patient derived flow and viscosity data. The intravascular ultrasound data allowed us to measure local WT and remodeling in the main branch. RESULTS: The lumen reconstruction procedure was successful and it was shown that the impact of the side branch on SS distribution in the main branch diminished within 3mm. Distal to the bifurcation, two continuous regions in the main branch were identified. In the proximal region, we observed lumen preservation, and expansive remodeling. Although a plaque was observed in the low SS region at the non-divider wall, no relationship between SS and WT was found. In the distal region, we observed lumen narrowing and a significant positive relationship between SS and WT. CONCLUSIONS: A new imaging technique was applied to generate a 3-D reconstruction of a human coronary artery bifurcation in vivo. The observed relationship between SS, WT and remodeling in this specific patient illustrates the spatial heterogeneity of the atherosclerosis in the vicinity of arterial bifurcations.
机译：目的：冠状动脉分叉是动脉粥样硬化和扩张性重塑的好发部位，后者与斑块易损性有关。两者都与血流引起的切应力（SS）有关。我们提出了一种在体内产生冠状动脉分叉的3-D重建的新方法，并研究了SS，壁厚（WT）和重塑之间的关系。方法：结合血管内超声和双平面血管造影获得分叉主分支的患者特异性3-D重建，而侧支的3-D腔仅基于双平面血管造影。将这两个数据集融合在一起，并使用计算方法使用患者得出的流量和粘度数据确定SS分布。血管内超声数据使我们能够测量局部分支的WT和重塑。结果：管腔重建过程成功，结果表明侧分支对主分支中SS分布的影响在3mm内减小。在分叉的远端，确定了主分支中的两个连续区域。在近端区域，我们观察到了管腔的保留和扩张的重塑。尽管在非分隔壁的低SS区域观察到了一个噬菌斑，但未发现SS与WT之间的关系。在远端区域，我们观察到管腔变窄以及SS和WT之间存在显着的正相关。结论：一种新的成像技术被应用于体内人冠状动脉分叉的3-D重建。在该特定患者中观察到的SS，WT与重塑之间的关系说明了在动脉分叉处动脉粥样硬化的空间异质性。

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