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首页> 外文期刊>Journal of biomedical materials research, Part A >Silicate, borosilicate, and borate bioactive glass scaffolds with controllable degradation rate for bone tissue engineering applications. II. In vitro and in vivo biological evaluation
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Silicate, borosilicate, and borate bioactive glass scaffolds with controllable degradation rate for bone tissue engineering applications. II. In vitro and in vivo biological evaluation

机译：具有可控降解速率的硅酸盐，硼硅酸盐和硼酸盐生物活性玻璃支架，适用于骨组织工程应用。二。体外和体内生物学评估

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In Part I, the in vitro degradation of bioactive glass scaffolds with a microstructure similar to that of human trabecular bone, but with three different compositions, was investigated as a function of immersion time in a simulated body fluid. The glasses consisted of a silicate (13-93) composition, a borosilicate composition (designated 13-93B1), and a borate composition (13-93B3), in which one-third or all of the SiO2 content of 13-93 was replaced by B2O3, respectively. This work is an extension of Part I, to investigate the effect of the glass composition on the in vitro response of osteogenic MLO-A5 cells to these scaffolds, and on the ability of the scaffolds to support tissue infiltration in a rat subcutaneous implantation model. The results of assays for cell viability and alkaline phosphatase activity showed that the slower degrading silicate 13-93 and borosilicate 13-93B1 scaffolds were far better than the borate 13-93B3 scaffolds in supporting cell proliferation and function. However, all three groups of scaffolds showed the ability to support tissue infiltration in vivo after implantation for 6 weeks. The results indicate that the required bioactivity and degradation rate may be achieved by substituting an appropriate amount of SiO2 in 13-93 glass with B2O3, and that these trabecular glass scaffolds could serve as substrates for the repair and regeneration of contained bone defects.
机译：在第一部分中，对生物活性玻璃支架的体外降解进行了研究，该支架的微观结构与人的小梁骨相似，但具有三种不同的组成，这是其在模拟体液中浸泡时间的函数。玻璃由硅酸盐（13-93）成分，硼硅酸盐成分（标记为13-93B1）和硼酸盐成分（13-93B3）组成，其中13-93的SiO2含量的三分之一或全部被替换分别由B2O3这项工作是第一部分的扩展，目的是研究玻璃组合物对成骨MLO-A5细胞对这些支架的体外反应以及在大鼠皮下植入模型中支架支持组织浸润的能力的影响。细胞活力和碱性磷酸酶活性的测定结果表明，降解较慢的硅酸盐13-93和硼硅酸盐13-93B1支架在支持细胞增殖和功能方面远优于硼酸盐13-93B3支架。然而，所有三组支架在植入6周后均表现出支持体内组织浸润的能力。结果表明，通过用B2O3代替13-93玻璃中的适量SiO2，可以实现所需的生物活性和降解速率，并且这些小梁玻璃支架可以用作修复和再生所含骨缺损的基质。

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