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首页> 外文期刊>Journal of biomedical materials research, Part A >Silicate, borosilicate, and borate bioactive glass scaffolds with controllable degradation rate for bone tissue engineering applications. II. In vitro and in vivo biological evaluation
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Silicate, borosilicate, and borate bioactive glass scaffolds with controllable degradation rate for bone tissue engineering applications. II. In vitro and in vivo biological evaluation

机译：硅酸盐，硼硅酸盐和硼酸盐生物活性玻璃支架，具有可控的骨组织工程应用的降解速率。 II。 体外和体内生物评估

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In Part I, the in vitro degradation of bioactive glass scaffolds with a microstructure similar to that of human trabecular bone, but with three different compositions, was investigated as a function of immersion time in a simulated body fluid. The glasses consisted of a silicate (13-93) composition, a borosilicate composition (designated 13-93B1), and a borate composition (13-93B3), in which one-third or all of the SiO2 content of 13-93 was replaced by B2O3, respectively. This work is an extension of Part I, to investigate the effect of the glass composition on the in vitro response of osteogenic MLO-A5 cells to these scaffolds, and on the ability of the scaffolds to support tissue infiltration in a rat subcutaneous implantation model. The results of assays for cell viability and alkaline phosphatase activity showed that the slower degrading silicate 13-93 and borosilicate 13-93B1 scaffolds were far better than the borate 13-93B3 scaffolds in supporting cell proliferation and function. However, all three groups of scaffolds showed the ability to support tissue infiltration in vivo after implantation for 6 weeks. The results indicate that the required bioactivity and degradation rate may be achieved by substituting an appropriate amount of SiO2 in 13-93 glass with B2O3, and that these trabecular glass scaffolds could serve as substrates for the repair and regeneration of contained bone defects.
机译：在第一部分中，在模拟体液中浸入时间的函数，研究了与人小梁骨的微观结构相似的微观结构的生物活性玻璃支架的体外降解，但用三种不同的组合物研究。玻璃由硅酸盐（13-93）组合物，硼硅酸盐组合物（指定为13-93b1）和硼酸盐组合物（13-93b3），其中三分之一或所有SiO 2含量为13-93含量分别由B2O3分别。这项工作是第一部分的延伸，探讨玻璃组合物对这些支架上的骨质酸下MLO-A5细胞的体外反应的影响，以及支架支持在大鼠皮下植入模型中的组织浸润的能力。用于细胞活力和碱性磷酸酶活性的测定结果表明，较慢的降解硅酸盐13-93和硼硅酸盐13-93b1支架远远优于硼酸盐13-93b3支架在支持细胞增殖和功能。然而，所有三组支架都显示出在植入后体内组织浸润的能力6周。结果表明，通过用B2O3代替13-93玻璃中的适量的SiO 2可以实现所需的生物活性和降解速率，并且这些小梁玻璃支架可以用作含有骨缺损的修复和再生的底物。

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