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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Viscoelasticity of hyaluronic acid-gelatin hydrogels for vocal fold tissue engineering
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Viscoelasticity of hyaluronic acid-gelatin hydrogels for vocal fold tissue engineering

机译：透明质酸-明胶水凝胶在声带组织工程中的粘弹性

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Crosslinked injectable hyaluronic acid (HA)-gelatin (Ge) hydrogels have remarkable viscoelastic and biological properties for vocal fold tissue engineering. Patient-specific tuning of the viscoelastic properties of this injectable biomaterial could improve tissue regeneration. The frequency-dependent viscoelasticity of crosslinked HA-Ge hydrogels was measured as a function of the concentration of HA, Ge, and crosslinker. Synthetic extracellular matrix hydrogels were fabricated using thiol-modified HA and Ge, and crosslinked by poly(ethylene glycol) diacrylate. A recently developed characterization method based on Rayleigh wave propagation was used to quantify the frequency-dependent viscoelastic properties of these hydrogels, including shear storage and loss moduli, over a broad frequency range; that is, from 40 to 4000 Hz. The viscoelastic properties of the hydrogels increased with frequency. The storage and loss moduli values and the rate of increase with frequency varied with the concentrations of the constituents. The range of the viscoelastic properties of the hydrogels was within that of human vocal fold tissue obtained from in vivo and ex vivo measurements. Frequency-dependent parametric relations were obtained using a linear least-squares regression. The results are useful to better fine-tune the storage and loss moduli of HA-Ge hydrogels by varying the concentrations of the constituents for use in patient-specific treatments. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 283-290, 2016.
机译：交联的可注射的透明质酸（HA）-明胶（Ge）水凝胶对声带组织工程具有显着的粘弹性和生物学特性。特定于患者的这种可注射生物材料的粘弹性调节可以改善组织再生。测量交联的HA-Ge水凝胶的频率依赖性粘弹性，其是HA，Ge和交联剂浓度的函数。合成的细胞外基质水凝胶是使用硫醇修饰的HA和Ge制备的，并通过聚乙二醇二丙烯酸酯交联。最近开发的基于瑞利波传播的表征方法用于量化这些水凝胶的频率依赖性粘弹性质，包括较宽的频率范围内的剪切储能和损耗模量。即从40到4000 Hz。水凝胶的粘弹性质随频率增加。储能和损耗模量值以及频率增加的速率随成分的浓度而变化。水凝胶的粘弹性性质的范围在从体内和离体测量获得的人声带组织的范围内。使用线性最小二乘回归获得频率相关的参数关系。通过改变用于患者特定治疗的成分的浓度，这些结果有助于更好地微调HA-Ge水凝胶的存储和损耗模量。 （c）2015 Wiley Periodicals，Inc.J Biomed Mater Res B部分：Appl Biomater，104B：283-290，2016。

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