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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Mineralization processes in demineralized bone matrix grafts in human maxillary sinus floor elevations.
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Mineralization processes in demineralized bone matrix grafts in human maxillary sinus floor elevations.

机译：人上颌窦底高程中去矿质骨基质移植物中的矿化过程。

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摘要

For reconstruction of the severely resorbed lateral maxilla for dental implant placement, one of the successful procedures is to elevate the maxillary sinus floor by implanting demineralized bone matrix (DBM). We studied bone formation in DBM grafts in the lateral maxilla in humans by means of histology and histomorphometry. Six months after grafting, at the time of dental implantation biopsies were taken from the grafted areas of seven patients. All biopsies contained mineralized matrix (MM) in the grafted area. At close inspection, three types of mineralization were found. First, lamellar biomineralization was seen in and near the maxillary host bone. Second, remineralization was observed in some particles that probably had not been completely demineralized. In the area connecting the graft and host bone, where woven bone was formed against DBM particles, a third mechanism was detected. In this case many dotlike foci of remineralization appeared close to the bone-DBM interface. The remineralized DBM and woven bone were both subsequently remodeled. Bone formation was most active in the area adjoining the maxillary host bone. We conclude that in human sinus floor elevation, allogenic DBM increases mineralized tissue volume by osteoconduction that is supported by the remineralization processes. Osteoinduction by this material seems questionable. Copyright 1999 John Wiley & Sons, Inc.
机译：为了重建严重吸收的外侧上颌骨以用于种植牙种植体，成功的方法之一是通过植入脱矿质骨基质（DBM）来升高上颌窦底。我们通过组织学和组织形态学方法研究了人类上颌外侧DBM移植物中的骨形成。移植后六个月，在牙科植入时，从七名患者的移植区域进行了活检。所有活检均在移植区域内包含矿化基质（MM）。经过仔细检查，发现了三种矿化类型。首先，在上颌宿主骨中和附近发现了层状生物矿化。第二，在一些可能尚未完全脱矿的颗粒中观察到了再矿化。在连接移植物和宿主骨的区域中，针对DBM颗粒形成了编织骨，发现了第三种机制。在这种情况下，许多再矿化的点状焦点出现在骨骼-DBM界面附近。再矿化的DBM和编织骨随后都进行了重塑。骨形成在上颌骨附近区域最活跃。我们得出的结论是，在人的窦底抬高中，同种异体DBM通过骨矿化过程支持的骨传导增加矿化的组织体积。这种材料的骨诱导似乎值得怀疑。版权所有1999 John Wiley＆Sons，Inc.

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