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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Thickness of fibrous capsule after implantation of hydroxyapatite in subcutaneous tissue in rats.
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Thickness of fibrous capsule after implantation of hydroxyapatite in subcutaneous tissue in rats.

机译：羟基磷灰石植入大鼠皮下组织后纤维囊的厚度

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摘要

The present study evaluates in rats the histomorphometrical thickness of fibrous capsules that surround hydroxyapatite (HA) disks after implantation. HA disks were implanted into the subcutaneous tissue of 79 rats for 1 day to 20 months. Decalcified histological sections stained with hematoxylin and eosin were examined. Fibrous capsule thickness (FCT) was measured using an objective micrometer. On the fourteenth day, primary fibrous capsules formed around implants. From that time point FCT increased with time of implantation. Within a given sample, FCT differed from one portion of the fibrous capsule to another, depending on which site faced the disks. FCT was thickest at the upper and lower portions of the disks, thinner at the lateral portions, and thinnest at the upper and lower ring-shaped portions. Two possible explanations for the above findings are discussed in this paper: (1) The area of contact between disk and tissue differs. (2) Chemical stimulation of implanted material caused by demineralization and remineralization may result from the varying thicknesses of fibrous capsules. FCT from upper and lower portions of HA disks increased by over 200% in the first 10 months and steadily increased about 20% over the next 10 months. Many studies have concluded that HA is useful for reconstructive surgery, so the long-term effects of FCT need further study.
机译：本研究评估了大鼠植入后围绕羟基磷灰石（HA）盘的纤维囊的组织形态学厚度。将HA盘植入79只大鼠的皮下组织中，持续1天至20个月。检查了苏木精和曙红染色的脱钙组织切片。使用物镜千分尺测量纤维囊厚度（FCT）。在第十四天，在植入物周围形成初级纤维囊。从那时起，FCT随着植入时间的增加而增加。在给定的样品中，FCT从纤维囊的一部分到另一部分，取决于面对圆盘的位置。 FCT在磁盘的上部和下部最厚，在横向部分更薄，在上部和下部环形部分最薄。本文讨论了上述发现的两种可能的解释：（1）椎间盘与组织之间的接触面积不同。 （2）脱矿质和再矿化引起的植入材料的化学刺激可能是由于纤维囊厚度的变化而引起的。在最初的10个月中，来自HA磁盘上部和下部的FCT增长了200％以上，在接下来的10个月中稳定增长了约20％。许多研究得出的结论是，HA在重建手术中很有用，因此FCT的长期效果有待进一步研究。

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