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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Fatigue Properties of Hydroxyapatite-Coated Dental Implant after Exposure to a Periodontal Pathogen
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Fatigue Properties of Hydroxyapatite-Coated Dental Implant after Exposure to a Periodontal Pathogen

机译：牙周病原体暴露后羟基磷灰石涂层牙植入物的疲劳特性

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We studied the fatigue properties of rods (4 mm diameter) of hydroxyapatite coated, titanium alloy implant material after it was exposed to a periodontal pathogen, Actinobacilus actinomvcetemcomitans (Aa). We varied the crystallinity of the hydroxyapatite (HA) coating in these rods to the levels of, 60.5percent, 52.8percent, and 47.8percent. Each rod was first inoculated with Aa in the log phase of its growth cycle. After 48 h, we counted the adhered cells. We measured the dissolution of HA coating due to bacterial exposure alone by deter-mining the calcium and phosphate concentrations in the bacterial growth media. Once the adherent bacteria were removed from these rods, we subjected them to 5 million cycles of fatigue testing after immersion in Lactated Ringer's solution. We then determined the calcium and phosphate concentrations in the fatigue media. We found additional coating loss after fatiguing of the samples. This coating loss was a cumulative effect of bacterial exposure and fatigue loading of the hydroxyapatite-coated dental implant alloy. The lower crystallinity sample showed a higher loss of coating within the range of crystallinity studied here. The HA coating in implants during clinical use may undergo such changes, because they are exposed to the same bacteria.
机译：我们研究了羟基磷灰石涂覆的钛合金植入物材料暴露于牙周病原体放线杆菌Actaobacilus actinomvcetemcomitans（Aa）后的疲劳性能（直径4 mm）。我们将这些棒中的羟基磷灰石（HA）涂层的结晶度更改为60.5％，52.8％和47.8％的水平。在其生长周期的对数阶段，首先向每个棒接种Aa。 48小时后，我们对粘附的细胞进行计数。我们通过确定细菌生长培养基中的钙和磷酸盐浓度，测量了仅由于细菌暴露导致的HA涂层的溶解。将附着的细菌从这些棒中去除后，我们将其浸入乳酸林格氏液中后进行了500万次疲劳测试。然后，我们确定了疲劳介质中的钙和磷酸盐浓度。在对样品进行疲劳处理后，我们发现了额外的涂层损失。这种涂层损失是细菌暴露和羟基磷灰石涂层牙科植入物合金疲劳负荷的累积效应。较低结晶度的样品在此处研究的结晶度范围内显示出较高的涂层损失。在临床使用期间，植入物中的HA涂层可能会发生这种变化，因为它们与相同的细菌接触。

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