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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Interactions between MC3T3-E1 cells and textured Ti6Al4V surfaces
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Interactions between MC3T3-E1 cells and textured Ti6Al4V surfaces

机译：MC3T3-E1细胞与带纹理的Ti6Al4V表面之间的相互作用

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This paper presents the results of an experimental study of the interactions between MC3T3-E1 (mouse calvarian) cells and textured Ti6Al4V surfaces, including surfaces produced by laser microgrooving; blasting with alumina particles; and polishing. The multiscale interactions between MC3T3-E1 cells and these textured surfaces are studied using a combination of optical scanning transmission electron microscopy and atomic force microscopy. The potential cytotoxic effects of microchemistry on cell-surface interactions also are considered in studies of cell spreading and orientation over 9-day periods. These studies show that cells on microgrooved Ti6Al4V geometries that are 8 or 12 mu m deep undergo contact guidance and limited cell spreading. Similar contact guidance is observed on the surfaces of diamond-polished surfaces on which nanoscale grooves are formed due to the scratching that occurs during polishing. In contrast, random cell orientations are observed on alumina-blasted Ti6Al4V surfaces. The possible effects of surface topography are discussed for scar-tissue formation and improved cell-surface integration.
机译：本文介绍了MC3T3-E1（小鼠颅盖骨）细胞与带纹理的Ti6Al4V表面（包括通过激光微刻槽产生的表面）之间相互作用的实验研究结果;用氧化铝颗粒喷砂;和抛光。结合使用光学扫描透射电子显微镜和原子力显微镜研究了MC3T3-E1细胞与这些纹理化表面之间的多尺度相互作用。微观化学对细胞表面相互作用的潜在细胞毒性作用也被研究了长达9天的细胞扩散和定向研究。这些研究表明，在微槽Ti6Al4V几何结构（深度为8或12微米）上的细胞会受到接触引导和有限的细胞扩散。由于在抛光过程中发生的刮擦，在形成纳米级凹槽的金刚石抛光表面的表面上观察到类似的接触引导。相反，在喷氧化铝的Ti6Al4V表面观察到随机的细胞取向。讨论了表面形貌可能对疤痕组织形成和改善的细胞表面整合的影响。

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