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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Evaluation of thermal- and photo-crosslinked biodegradable poly(propylene fumarate)-based networks
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Evaluation of thermal- and photo-crosslinked biodegradable poly(propylene fumarate)-based networks

机译：热和光交联的可生物降解的聚富马​​酸丙二酯网络的评估

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摘要

Biodegradable networks of poly(propylene fumarate) (PPF) and the crosslinking reagent poly(propylene fumarate)-diacrylate (PPF-DA) were prepared with thermal-and photo-initiator systems. Thermal-crosslinking was performed with benzoyl peroxide (BP), which is accelerated by N,N-dimethyl-p-toluidine (DMT) and enables injection and in situ polymerization. Photo-crosslinking was accomplished with bis(2,4,6-trimethylbenzoyl) phenylphosphine oxide (BAPO), which is activated by long-wavelength UV light and facilitates material processing with rapid manufacturing techniques, such as stereolithography. Networks were evaluated to assess the effects of the initiators and the PPF/PPF-DA double bond ratio on the mechanical properties. Regardless of the initiator system, the compressive properties of the PPF/PPF-DA networks increased as the double bond ratio decreased from 2 to 0.5. BAPO/UV-initiated networks were significantly stronger than those formed with BP/DMT. The compressive modulus of the photo- and thermal-crosslinked PPF/PPF-DA networks ranged from 310 +- 25 to 1270 +- 286 MPa and 75 +- 8 to 332 +- 89 MPa, respectively. The corresponding fracture strengths varied from 58 +- 7 to 129 +- 17 MPa and 31 +- 13 105+- 12 MPa. The mechanical properties were not affected by the initiator concentration. Characterization of the network structures indicated that BAPO was a more efficient initiator for the crosslinking of PPF/PPF-DA, achieving a higher double bond conversion and crosslinking density than its BP counterpart. Estimated average molecular weights between crosslinks (M_c) confirmed the effects of the initiators and PPF/PPF-DA double bond ratio on the mechanical properties. This work demonstrates the capability to control the properties of PPF/PPF-DA networks as well as their versatility to be used as an injectable material or a prefabricated implant.
机译：聚富马酸丙二酯（PPF）和交联剂聚富马酸丙二酯-二丙烯酸酯（PPF-DA）的生物降解网络是通过热引发剂和光引发剂体系制备的。用过氧化苯甲酰（BP）进行热交联，过氧化苯甲酰通过N，N-二甲基对甲苯胺（DMT）加速，并能够进行注射和原位聚合。用双（2,4,6-三甲基苯甲酰基）苯基膦氧化物（BAPO）完成光交联，该双膦氧化物被长波长紫外光激活，并通过诸如立体光刻的快速制造技术促进了材料加工。评估网络以评估引发剂和PPF / PPF-DA双键比率对机械性能的影响。无论引发剂系统如何，PPF / PPF-DA网络的压缩特性都随着双键比率从2降低到0.5而增加。 BAPO / UV引发的网络明显强于BP / DMT形成的网络。光和热交联的PPF / PPF-DA网络的压缩模量分别为310±25至1270±286MPa和75±8至332±89MPa。相应的断裂强度从58±7至129±17MPa和31±13105±12MPa变化。机械性能不受引发剂浓度的影响。网络结构的表征表明，BAPO是PPF / PPF-DA交联的更有效引发剂，比其BP对应物具有更高的双键转化率和交联密度。估计的交联之间的平均分子量（M_c）证实了引发剂和PPF / PPF-DA双键比率对机械性能的影响。这项工作证明了控制PPF / PPF-DA网络特性的能力以及它们用作注射材料或预制植入物的多功能性。

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