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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >The In Vitro Elution of Gentamicin Sulfate from a Commercially Available Gentamicin-Loaded Acrylic Bone Cement, VersaBond~(TM) AB
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The In Vitro Elution of Gentamicin Sulfate from a Commercially Available Gentamicin-Loaded Acrylic Bone Cement, VersaBond~(TM) AB

机译：从市售载有庆大霉素的丙烯酸骨水泥VersaBond〜（TM）AB进行硫酸庆大霉素的体外洗脱

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The present study was designed to yield results that would be used to contribute to the ongoing debate about the mechanism of the in vitro elution of an antibiotic from an antibiotic-loaded acrylic bone cement. To this end, the elution rates (R) of gentamicin sulfate (expressed as a weight percentage of the initial mass of the antibiotic in the specimen, normalized with respect to the duration of the test) from statically loaded (STATIC) and dynamically loaded (+ - 10 MPa; 2 Hz; until fracture; DYNAMIC) specimens fabricated from a commercially available acrylic bone cement (VersaBond~(?) AB), in phosphate-buffered saline solution at 37 deg C, were obtained with the use of a spectrophotometric method. There was evidence of microcracking in the fracture surfaces of DYNAMIC specimens, but no such evidence in the case of STATIC specimens. The surface area of the DYNAMIC specimens, during the tensile phase of the cyclical loading, was estimated to be about 3 percent larger than for the STATIC specimens (1742 mm~2 versus 1696 mm~2). The bulk porosities P of the specimens in both sets were also determined and found to not be statistically different, with P for the STATIC and DYNAMIC specimens being 8.55 + - 0.10 and 8.88 + - 0.18 percent, respectively. At the end of the test period, R was found to be 0.36 + - 0.20 and 1.28 + - 0.14 wt percent /day for the STATIC and DYNAMIC specimens, respectively. It is suggested that the present results provide support for the postulate that the elution mechanism of gentamicin in this cement is a surface phenomenon.
机译：本研究旨在产生可用于促进有关从载有抗生素的丙烯酸骨水泥中体外洗脱抗生素机理的辩论的结果。为此，从静态负载（静态）和动态负载（静态）得出硫酸庆大霉素的洗脱率（R）（表示为样品中抗生素初始质量的重量百分比，相对于测试持续时间标准化）。使用分光光度法，在磷酸盐缓冲的盐溶液中，获得由市售丙烯酸骨水泥（VersaBond〜（？）AB）制成的试样，试样为+-10 MPa; 2 Hz;直至断裂;动态试样。方法。在DYNAMIC标本的断裂表面有微裂纹的证据，但在STATIC标本的情况下则没有这种证据。估计DYNAMIC试样在周期性载荷拉伸阶段的表面积比STATIC试样的表面积大（1742 mm〜2比1696 mm〜2）大3％。还确定了两组样品的整体孔隙率P，发现它们之间没有统计学差异，其中静态和动态样品的P分别为8.55％±0.10和8.88±0.18％。在测试期结束时，发现静态和动态样品的R分别为0.36 +-0.20和1.28 +-0.14 wt％/天。建议该结果为以下假设提供支持：庆大霉素在该水泥中的洗脱机理是表面现象。

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