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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Functionalization of dental implant surfaces using adhesion molecules.
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Functionalization of dental implant surfaces using adhesion molecules.

机译：使用粘附分子对牙科植入物表面进行功能化。

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The aim of the present study was to test the hypothesis that organic coating of titanium screw implants that provides binding sites for integrin receptors can enhance periimplant bone formation. Ten adult female foxhounds received experimental titanium screw implants in the mandible 3 months after removal of all premolar teeth. Four types of implants were evaluated in each animal: (1) implants with machined titanium surface, (2) implants coated with collagen I, (3) implants with collagen I and cyclic RGD peptide coating (Arg-Gly-Asp) with low RGD concentrations (100 micromol/mL), and (4) implants with collagen I and RGD coating with high RGD concentrations (1000 micromol/mL). Periimplant bone regeneration was assessed histomorphometrically after 1 and 3 months in five dogs each by measuring bone implant contact (BIC) and the volume density of the newly formed periimplant bone (BVD). After 1 month, BIC was significantly enhanced only in the group of implants coated with the higher concentration of RGD peptides (p 0.026). Volume density of the newly formed periimplant bone was significantly higher in all implants with organic coating. No significant difference was found between collagen coating and RGD coatings. After 3 months, BIC was significantly higher in all implants with organic coating than in implants with machined surfaces. Periimplant BVD was significantly increased in all coated implants in comparison to machined surfaces also. It was concluded that organic coating of machined screw implant surfaces providing binding sites for integrin receptors can enhance bone implant contact and periimplant bone formation.
机译：本研究的目的是检验以下假说，即钛螺钉植入物的有机涂层可为整联蛋白受体提供结合位点，可增强植入物周围骨的形成。十只成年雌性猎狐犬在去除所有前磨牙后的三个月内，在下颌骨中接受了实验性钛螺钉植入物。在每只动物中评估了四种类型的植入物：（1）具有机械加工钛表面的植入物，（2）涂有胶原蛋白I的植入物，（3）胶原蛋白I和具有低RGD的环状RGD肽涂层（Arg-Gly-Asp）的植入物（100 micromol / mL），以及（4）胶原I和RGD涂层的植入物具有高RGD浓度（1000 micromol / mL）。通过测量骨植入物接触量（BIC）和新形成的植入物周围骨（BVD）的体积密度，对5只狗的1和3个月后的组织形态进行了形态学评估。 1个月后，BIC仅在涂有较高浓度RGD肽的植入物组中显着增强（p = 0.026）。在所有带有有机涂层的植入物中，新形成的植入物周围骨的体积密度明显更高。在胶原蛋白涂层和RGD涂层之间未发现显着差异。 3个月后，所有有机涂层植入物的BIC均显着高于机械加工表面植入物的BIC。与机械加工表面相比，在所有带涂层的种植体中，种植体周围的BVD均显着增加。结论是机械加工的螺钉植入物表面的有机涂层为整联蛋白受体提供了结合位点，可以增强骨植入物的接触和植入物周围的骨形成。

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