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首页> 外文期刊>Journal of Biomolecular Structure and Dynamics >Novel hybrid encodes both continuous and split tRNA genes?
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Novel hybrid encodes both continuous and split tRNA genes?

机译：新型杂种编码连续和分裂的tRNA基因？

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摘要

tRNAs are mostly transcribed from un-fragmented genes, but occasionally also from split genes, with separated 5' and 3' halves. A reanalysis of the existing data on Staphylothermus marinus and Staphylothermus hellenicus hints of a novel hybrid gene that encodes both an un-fragmented and a 5'-split-half together in one. The corresponding 3' complement-gene is located elsewhere on the genome. As un-fragmented, the hybrid gene transcribes to tRNA(lys)(TTT). But as 5'-half, it trans-splices with its 3'-complement-half to tRNA(lys)(CTT), the tRNA missed so far. This hybrid of the split and the un-fragmented in one suggests a deeper synergy between the two, and hints of co-evolution. Furthermore, in a subtle contrast to the widely held idea of conservation of 3'-half, it is precisely the 3'-half that varies in these two tRNAs; the 5'-half remains conserved.
机译：tRNA大多从未片段化的基因转录，但偶尔也从分裂的基因转录，分离的5'和3'一半。对海藻葡萄球菌和葡萄球菌葡萄球菌的现有数据的重新分析提示了一个新的杂种基因，该基因同时编码一个无片段的和一个5'分裂的一半。相应的3'补体基因位于基因组的其他位置。由于未片段化，杂交基因转录为tRNA（lys）（TTT）。但是作为5'-一半，它将其3'-补体一半反式剪接至tRNA（lys）（CTT），到目前为止，tRNA还是错过了。分裂与未分裂的混合体表明两者之间更深的协同作用，并暗示着共同发展。此外，与广泛保存的3'-一半保守概念形成微妙的对比，正是这两个tRNA的3'-一半发生了变化。 5'-一半保持保守。

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