...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cardiac surgery. >Slowed progression or elimination of atherosclerosis by low-frequency electrical impulses.
【24h】

Slowed progression or elimination of atherosclerosis by low-frequency electrical impulses.

机译：低频电脉冲减慢动脉粥样硬化的进展或消除。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: In our previous investigations we showed that electrical impulses (EI) can prevent the development of atherosclerosis if they began simultaneously with high cholesterol diet (HCD) or in the early stages of atherosclerosis (after three weeks of HCD only). In this investigation we demonstrated the slow progression or elimination of atherosclerosis by low-frequency EI in case of moderate atherosclerosis (after eight weeks of HCD). Methods: Series I rabbits (control group) were fed HCD for eight weeks. Series II rabbits were fed HCD for eight weeks and were then switched to normal diet for eight weeks (no EI). Series III rabbits were fed HCD for eight weeks and then switched to a normal diet with simultaneous EI (applied near the abdominal aorta) for eight weeks (3 V, 30 single impulses per minute, 24 hours/day). After euthanization, the level of atherosclerosis, percentage of surface area involved in the atherosclerosis process, and an atherosclerosis score were calculated in the aortic arch, thoracic and abdominal aorta. RESULTS: Statistically significant differences were seen in the level of atherosclerosis in the abdominal aorta between series III animals (0.4 +/- 0.2) and the other two groups: 1.5 +/- 0.4 in series I (HCD only), 1.2 +/- 0.3 in series II (HCD then normal diet). Gross examination of the surface also revealed statistically significant differences (p < 0.05) in the percentage of atherosclerosis between the control series I (30.1 +/- 4.1%) and series II (21.3 +/- 3.6%), compared with series III (5.5 +/- 5.4%). In addition, the atherosclerosis score was also significantly different: 45.8 +/- 3.9 in series I, 25.2 +/- 6.9 in series II, and 2.2 +/- 2.0 in series III (p < 0.05). CONCLUSION: Our study showed that, when applied near the abdominal aorta, low-frequency electrical impulses decrease atherosclerotic deposition in the abdominal aorta.
机译：背景：在我们先前的研究中，我们发现，如果电脉冲（EI）与高胆固醇饮食（HCD）同时开始或在动脉粥样硬化的早期阶段（仅在HCD的三周后）开始，则可以预防动脉粥样硬化的发展。在这项研究中，我们证明了在中度动脉粥样硬化（HCD八周后）的情况下，低频EI可以缓慢进展或消除动脉粥样硬化。方法：给I系列兔（对照组）喂食HCD 8周。对II系列兔子喂食HCD八周，然后改换正常饮食八周（无EI）。对III系列兔子进行HCD喂养八周，然后切换到同时进行EI（施加在腹主动脉附近）的正常饮食八周（3 V，每分钟30次单脉冲，每天24小时/天）。安乐死后，计算主动脉弓，胸主动脉和腹主动脉中的动脉粥样硬化水平，动脉粥样硬化过程涉及的表面积百分比以及动脉粥样硬化评分。结果：III系列动物（0.4 +/- 0.2）和其他两组之间，腹主动脉粥样硬化水平有统计学意义的差异：I系列（仅HCD）为1.5 +/- 0.4，1.2 +/- II系列0.3（HCD，然后正常饮食）。大体检查表面还显示，与系列III（I系列）（30.1 +/- 4.1％）和系列II（21.3 +/- 3.6％）相比，对照组I（30.1 +/- 4.1％）和II系列（21.3 +/- 3.6％）的动脉粥样硬化百分比具有统计学显着性差异（p <0.05）。 5.5 +/- 5.4％）。此外，动脉粥样硬化评分也有显着差异：第一系列为45.8 +/- 3.9，第二系列为25.2 +/- 6.9，第三系列为2.2 +/- 2.0（p <0.05）。结论：我们的研究表明，在腹主动脉附近应用低频电脉冲可减少腹主动脉中的动脉粥样硬化沉积。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号