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首页> 外文期刊>Journal of Cancer Research and Clinical Oncology >Expressions of MAGE-A10 and MAGE-A11 in breast cancers and their prognostic significance: a retrospective clinical study.
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Expressions of MAGE-A10 and MAGE-A11 in breast cancers and their prognostic significance: a retrospective clinical study.

机译：MAGE-A10和MAGE-A11在乳腺癌中的表达及其预后意义：一项回顾性临床研究。

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Melanoma-associated antigens-A (MAGE-A) family is a group of well-characterized cancer/testis antigens (CTA), because they are strictly tumor specific and are shared by many kinds of tumors. However, the expression pattern of MAGE-A10 and MAGE-A11 in breast cancer patients is still unclear. The purpose of our study is to investigate the expression pattern and prognostic significance of MAGE-A10 and MAGE-A11 in breast cancer patients.Formalin-fixed and paraffin-embedded tissues and the clinicopathological parameters from 75 primary breast cancer patients were collected. The expressions of MAGE-A10 and MAGE-A11 proteins were immunohistochemically detected, and the association of MAGE-A10 and MAGE-A11 expressions with the clinicopathological parameters and the survival of breast cancer patients were analyzed.The expression rates of MAGE-A10 and MAGE-A11 in breast cancer specimens were 73.3 and 52.0%, respectively. MAGE-A11 expression was more frequent in estrogen-receptor (ER)-positive breast carcinomas compared with ER-negative breast carcinomas (P = 0.004). MAGE-A11 expression was positively associated with HER-2 expression (P = 0.003). Overall survival of patients with MAGE-A11-negative expression was significantly longer than those patients with positive MAGE-A11 expression (P = 0.030), but no difference of overall survival was found between patients with MAGE-A10-negative and -positive expression (P = 0.881).MAGE-A10 and MAGE-A11 are tumor-specific antigens, and MAGE-A11 expression probably is a potential poor prognostic factor for breast cancer patients.
机译：黑色素瘤相关抗原-A（MAGE-A）家族是一组特征明确的癌症/睾丸抗原（CTA），因为它们严格地是肿瘤特异性的，并且被多种肿瘤所共有。然而，乳腺癌患者中MAGE-A10和MAGE-A11的表达模式仍不清楚。本研究的目的是探讨MAGE-A10和MAGE-A11在乳腺癌患者中的表达模式和预后意义。收集75例原发性乳腺癌患者中福尔马林固定和石蜡包埋的组织以及临床病理参数。免疫组化检测MAGE-A10和MAGE-A11蛋白的表达，分析MAGE-A10和MAGE-A11表达与乳腺癌患者的临床病理参数和生存率的关系。MAGE-A10和MAGE的表达率乳腺癌标本中的-A11分别为73.3％和52.0％。与雌激素受体阴性乳腺癌相比，雌激素受体（ER）阳性乳腺癌中MAGE-A11的表达更为频繁（P = 0.004）。 MAGE-A11表达与HER-2表达呈正相关（P = 0.003）。 MAGE-A11阴性表达患者的总生存期显着长于MAGE-A11阳性表达患者（P = 0.030），但MAGE-A10阴性和阳性表达患者之间的总生存期无差异（ P = 0.881）。MAGE-A10和MAGE-A11是肿瘤特异性抗原，MAGE-A11表达可能是乳腺癌患者潜在的不良预后因素。

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