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首页> 外文期刊>Journal of child neurology >Neurotrophin-3 levels in cerebrospinal fluid from children with bacterial meningitis, viral meningitis, or encephalitis.
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Neurotrophin-3 levels in cerebrospinal fluid from children with bacterial meningitis, viral meningitis, or encephalitis.

机译：儿童细菌性脑膜炎，病毒性脑膜炎或脑炎患儿脑脊液中Neurotrophin-3的水平。

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摘要

Neurotrophin-3 levels were measured in the cerebrospinal fluid of 35 patients with bacterial meningitis, viral meningitis, or encephalitis by two-site enzyme immunoassay. Elevated cerebrospinal fluid levels of neurotrophin-3 were demonstrated in 8 of 18 patients with bacterial meningitis. Follow-up examination of the eight patients at the convalescent stage showed diminished cerebrospinal fluid levels of neurotrophin-3. In contrast, none of the 17 patients with viral meningitis or encephalitis showed an elevation of neurotrophin-3 levels in cerebrospinal fluid. No relationships were observed between neurotrophin-3 levels and cerebrospinal fluid cell numbers, cerebrospinal fluid protein levels, serum C-reactive protein concentrations, or outcome in bacterial meningitis. Since neurotrophin-3 is involved in the survival of neurons and the modulation of the immune system, neurotrophin-3 could play a neuroprotective or immunomodulatory role in bacterial meningitis.
机译：通过两点酶免疫法测定了35例细菌性脑膜炎，病毒性脑膜炎或脑炎患者的脑脊液中Neurotrophin-3的水平。在18例细菌性脑膜炎患者中，有8例脑脊液中神经营养蛋白3水平升高。在恢复期对八名患者进行的随访检查显示，神经营养素3的脑脊液水平降低。相反，在17例病毒性脑膜炎或脑炎患者中，脑脊液中神经营养蛋白3水平均未升高。在神经营养蛋白3水平与脑脊髓液细胞数量，脑脊髓液蛋白水平，血清C反应蛋白浓度或细菌性脑膜炎预后之间未发现相关性。由于Neurotrophin-3参与神经元的存活和免疫系统的调节，因此Neurotrophin-3可以在细菌性脑膜炎中发挥神经保护或免疫调节作用。

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