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首页> 外文期刊>Journal of cardiovascular pharmacology and therapeutics >Clinical applications of bivalirudin in the cardiac catheterization laboratory.
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Clinical applications of bivalirudin in the cardiac catheterization laboratory.

机译：比伐卢定在心脏导管实验室中的临床应用。

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摘要

Heparin has been used in the catheterization laboratory to prevent ischemic complications of percutaneous coronary intervention (PCI). Bivalirudin, a direct thrombin inhibitor, is an anticoagulant that has several pharmacologic advantages over heparin, and it has been proposed that bivalirudin is superior to heparin in its ability to prevent bleeding complications of PCI. As such, there have been a variety of large prospective clinical trials comparing bivalirudin and heparin over the past 13 years. The results of these trials have prompted the general acceptance of bivalirudin as a safe alternative to heparin use during PCI, and bivalirudin has been given a class 1 recommendation by the American College of Cardiology/American Heart Association (ACC/AHA) guidelines for a variety of clinical indications. This article will review the data supporting the use of bivalirudin in the cardiac catheterization laboratory and describe several advantages of bivalirudin over traditional heparin use. We also include a discussion of the use of bivalirudin in conjunction with other medications that are frequently used in the catheterization laboratory. We end with an analysis of the economic differences between bivalirudin and heparin and the impact that financial factors may have on the choice of anticoagulant.
机译：肝素已在导管实验室中用于预防经皮冠状动脉介入治疗（PCI）的缺血并发症。比伐卢定是一种直接的凝血酶抑制剂，是一种抗凝剂，具有比肝素更多的药理优势，并且有人提出，比伐卢定在预防PCI出血并发症方面的能力优于肝素。因此，在过去的13年中，已有许多大型前瞻性临床试验比较了比伐卢定和肝素。这些试验的结果促使人们普遍接受比伐卢定作为PCI期间使用肝素的安全替代品，并且美国心脏病学会/美国心脏协会（ACC / AHA）指南将比伐卢定评为1类推荐临床适应症。本文将回顾支持比伐卢定在心脏导管实验室中使用的数据，并描述比伐卢定相对于传统肝素使用的若干优点。我们还讨论了比伐卢定与导管实验室中常用的其他药物联合使用的问题。我们最后分析了比伐卢定和肝素之间的经济差异，以及财务因素可能对抗凝剂选择的影响。

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