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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Effects of combined estrogen and progesterone on brain infarction in reproductively senescent female rats.
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Effects of combined estrogen and progesterone on brain infarction in reproductively senescent female rats.

机译：雌激素和孕酮联合对生殖衰老雌性大鼠脑梗死的影响。

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Recent data from the Women's Health Initiative have highlighted many fundamental issues about the utility and safety of long-term estrogen use in women. Current hormone replacement therapy for postmenopausal women incorporates progestin with estrogen, but it is uncertain if combined therapy provides major cerebrovascular risks or benefits to these women. No experimental animal stroke studies have examined combined hormone administration. The authors tested the hypothesis that combined hormone treatment reduces ischemic injury in middle-aged female rat brain. Reproductively senescent female rats underwent 2-hour middle cerebral artery occlusion (MCAO) followed by 22 hours reperfusion. Estrogen implants were placed subcutaneously at least 7 days before MCAO, and progesterone intraperitoneal injections were given 30 minutes before MCAO, at initiation, and at 6 hours of reperfusion. Rats received no hormone, a 25-microg estrogen implant, a 25-microg estrogen implant plus 5 mg/kg intraperitoneal progesterone, or 5 mg/kg intraperitoneal progesterone. Cortical, caudoputamen, and total infarct volumes were assessed by 2,3,5-triphenyltetrazolium chloride staining and digital image analysis at 22 hours reperfusion. Cortical and total infarct volumes, except in the acute progesterone-treated group, were significantly attenuated in all estrogen-alone and combined hormone-treated groups. There were no significant differences in caudoputamen infarct volumes in all hormone-treated groups as compared with untreated rats. These data have potential clinical implications relative to stroke for postmenopausal women taking combined hormone replacement therapy.
机译：妇女健康倡议的最新数据突出表明了长期使用雌激素对妇女的实用性和安全性的许多基本问题。目前用于绝经后妇女的激素替代疗法将孕激素与雌激素结合在一起，但是尚不确定联合疗法是否会对这些妇女产生主要的脑血管风险或益处。没有实验性动物卒中研究​​检查过激素联合给药。作者检验了以下假设：激素联合治疗可减轻中年雌性大鼠大脑的缺血性损伤。生殖衰老的雌性大鼠进行2小时的大脑中动脉闭塞（MCAO），然后进行22小时的再灌注。将雌激素植入物至少在MCAO之前7天皮下放置，并在MCAO之前，开始时和再灌注6小时时进行腹膜内孕激素注射。大鼠未接受激素，25微克雌激素植入物，25微克雌激素植入物加上5 mg / kg腹膜内孕激素或5 mg / kg腹膜内孕激素。皮质，caudoputamen和总梗死体积通过2,3,5-三苯基四唑氯化物染色和22小时再灌注后的数字图像分析进行评估。在所有单独使用雌激素和联合激素治疗的组中，除急性孕激素治疗组外，皮层和总梗死体积均明显减轻。与未治疗的大鼠相比，所有激素治疗组的caudoputamen梗死体积均无显着差异。这些数据对于接受联合激素替代治疗的绝经后妇女具有相对于中风的潜在临床意义。

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