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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Neuroprotective role of lactate after cerebral ischemia.
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Neuroprotective role of lactate after cerebral ischemia.

机译：乳酸对脑缺血的神经保护作用。

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摘要

It is well established that lactate can be used as an energy substrate by the brain by conversion to pyruvate and a subsequent oxidation in the mitochondria. Knowing the need for readily metabolizable substrates directly after ischemia and the protective effect of lactate after excitotoxicity, the aim of this study was to investigate whether lactate administration directly after ischemia could be neuroprotective. In vitro, the addition of 4 mmol/L L-lactate to the medium of rat organotypic hippocampal slices, directly after oxygen and glucose deprivation (OGD), protected against neuronal death, whereas a higher dose of 20 mmol/L was toxic. In vivo, after middle cerebral artery occlusion in the mouse, an intracerebroventricular injection of 2 microL of 100 mmol/L L-lactate, immediately after reperfusion, led to a significant decrease in lesion size, which was more pronounced in the striatum, and an improvement in neurologic outcome. A later injection 1 h after reperfusion did not reduce lesion size, but significantly improved neurologic outcome, which is an important point in the context of a potential clinical application. Therefore, a moderate increase in lactate after ischemia may be a therapeutic tool.
机译：众所周知，乳酸可以通过转化为丙酮酸和随后的线粒体氧化而被大脑用作能量底物。已知缺血后直接需要易于代谢的底物以及兴奋性中毒后乳酸的保护作用，本研究的目的是研究缺血后直接给予乳酸是否具有神经保护作用。在体外，在剥夺氧气和葡萄糖（OGD）后立即向大鼠器官型海马切片的培养基中添加4 mmol / L L-乳酸可防止神经元死亡，而更高剂量的20 mmol / L则具有毒性。在体内，在小鼠大脑中动脉闭塞后，再灌注后立即向脑室内注射2 microL 100 mmol / L L-乳酸，导致病变大小明显减少，在纹状体中更为明显。神经功能改善。再灌注后1小时再注射并没有减少病灶的大小，但是显着改善了神经系统的预后，这在潜在的临床应用中很重要。因此，缺血后乳酸的适度增加可能是一种治疗手段。

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