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首页> 外文期刊>Journal of Cell Science >The Arabidopsis SKP1 homolog ASK1 controls meiotic chromosome remodeling and release of chromatin from the nuclear membrane and nucleolus
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The Arabidopsis SKP1 homolog ASK1 controls meiotic chromosome remodeling and release of chromatin from the nuclear membrane and nucleolus

机译：拟南芥SKP1同源物ASK1控制减数分裂染色体重塑和染色质从核膜和核仁的释放

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During early stages of meiotic prophase I the nucleus undergoes considerable reorganization, including the clustering of telomeres, the release of contacts between chromosomes and the nuclear membrane, the reorganization of the nucleolus, and chromatin remodeling. Using a light squashing technique for the analysis of meiotic chromosomes along with fluorescent in situ hybridization, transmission electron microscopy and immunolocalization studies with antibodies to modified histones, we demonstrate that ASK1 is essential for early nuclear reorganization events. A relatively large number of meiotic alterations have been identified in ask1-1 plants. We show that many of these defects, including alterations in homolog pairing, nucleolus migration and the missegregation of chromosomes, may arise from alterations in chromatin structure and the inability of chromosomes to resolve and release properly from the nuclear membrane and nucleolus during leptotene. These results raise the interesting possibility that ASK1 controls chromatin structure by targeting of either an early regulator of meiotic progression or possibly matrix attachment proteins for destruction.
机译：在减数分裂前期I的早期阶段，核经历了相当大的重组，包括端粒的聚集，染色体与核膜之间接触的释放，核仁的重组以及染色质的重塑。使用光挤压技术分析减数分裂染色体以及荧光原位杂交，透射电子显微镜和免疫组化研究，以修饰组蛋白的抗体，我们证明了ASK1对于早期核重组事件至关重要。在ask1-1植物中已经鉴定出相对大量的减数分裂改变。我们表明，许多这些缺陷，包括同源配对的改变，核仁迁移和染色体的失聚，可能是由染色质结构的改变以及染色体无法在瘦素期间从核膜和核仁中正确解析和释放而引起的。这些结果提出了有趣的可能性，即ASK1通过靶向减数分裂进程的早期调节剂或可能破坏基质的附着蛋白来控制染色质结构。

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