Inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism.

Fu M; Silverman RB

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism.

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Inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism.

机译：（S）-4-氨基-4,5-二氢-2-呋喃羧酸使γ-氨基丁酸氨基转移酶失活不会通过预期的芳构化机理进行。

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摘要

Inactivation of pyridoxal 5'-phosphate (PLP)-dependent gamma-aminobutryic acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid (SADFA) gives pyridoxamine 5'-phosphate, not the expected SADFA-PLP aromatization product. Inactivation appears to proceed by a Michael addition/hydrolysis mechanism instead.

机译：（S）-4-氨基-4,5-二氢-2-呋喃羧酸（SADFA）使吡ido醛5'-磷酸（PLP）依赖性的γ-氨基丁酸氨基转移酶失活产生吡ido胺5'-磷酸，而不是预期的SADFA -PLP芳构化产品。灭活似乎是通过迈克尔加成/水解机制进行的。

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《Bioorganic and Medicinal Chemistry Letters》 |2004年第1期|共4页
作者
Fu M; Silverman RB;
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正文语种 eng
中图分类基础医学;
关键词
Inactivation; 2-furoic acid; Transaminases;

机译：灭活;2-糠酸;转氨酶;

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1. Inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism. [J] . Fu M, Silverman RB Bioorganic and Medicinal Chemistry Letters . 2004,第1期

机译：（S）-4-氨基-4,5-二氢-2-呋喃羧酸使γ-氨基丁酸氨基转移酶失活不会通过预期的芳构化机理进行。
2. Mechanism of Inactivation of Escherichia coli Aspartate Aminotransferase by (S)-4-Amino-4,5-dihydro-2-furancarboxylic Acid [J] . Liu DL, Pozharski E, Fu MM, Biochemistry . 2010,第49期

机译：（S）-4-氨基-4,5-二氢-2-呋喃甲酸使大肠杆菌天门冬氨酸氨基转移酶失活的机理
3. Chiral Discrimination among Aminotransferases: Inactivation by 4-Amino-4,5-dihydrothiophenecarboxylic Acid [J] . Bryan W. Lepore Dali Liu Ying Peng Mengmeng Fu Chad Yasuda James M. Manning Richard B. Silverman and Dagmar Ringe Biochemistry . 2010,第14期

机译：氨基转移酶之间的手性区分：灭活的4-氨基-4,5-二氢噻吩羧酸
4. ENZYMATIC BIOTRANSFORMATION OF ADIPIC ACID TO 6-AMINOCAPROIC ACID AND 1,6-HEXAMETHYLENEDIAMINE USING ENGINEERED CARBOXYLIC ACID REDUCTASES AND AMINOTRANSFERASES [C] . Anna Khusnutdinova, Tatiana Fedorchuk, Peter Stogios, Conference on biochemical and molecular engineering . 2019

机译：利用工程化的羧酸还原酶和氨基转移酶将己二酸向6-氨基癸二酸和1,6-己烯二胺进行酶促生物转化
5. Novel substrates and inhibitors of gamma-aminobutyric acid aminotransferase (GABA-AT): Design, synthesis, biological activities, and mechanistic studies. [D] . Yuan, Hai. 2006

机译：γ-氨基丁酸氨基转移酶（GABA-AT）的新型底物和抑制剂：设计，合成，生物学活性和机理研究。
6. (±)-(1S2R5S)-5-Amino-2-fluorocyclohex-3-ene Carboxylic Acid. A Potent GABA Aminotransferase Inactivator that Irreversibly Inhibits through an Elimination-Aromatization Pathway [O] . Zhiyong Wang, Hai Yuan, Dejan Nikolic, -1

机译：（±）-（1S2R5S）-5-氨基-2-氟环己基-3-烯羧酸一种有效的GABA氨基转移酶灭活剂可通过消除-芳香化途径不可逆地抑制
7. Mechanism of Inactivation ofEscherichia coliAspartate Aminotransferase by (S)-4-Amino-4,5-dihydro-2-furancarboxylic Acid, [O] . Dali Liu, Edwin Pozharski, Mengmeng Fu, 2010

机译：（S）-4-氨基-4,5-二氢-2-二叔转移酶的蛋白酶蛋白氨基氨基氨硅酸氨基氨基氨基氨基氨基转移酶的机制
8. The inactivation of catalytically active thermal polyanhydro-alpha-amino acids. /Inactivation of thermal polyamino acids/ [R] . Fox, S. W., Rohlfing, D. L. 1966

机译：催化活性热聚羟基-α-氨基酸的失活。 /热聚氨基酸的灭活/

Inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism.

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