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Commercially Available, FDA-approved Epigenetic Modifiers As Therapeutic Agents in Bacterial Infection

机译:市售的,FDA批准的表观遗传修饰剂作为细菌感染中的治疗剂

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摘要

Epigenetics represents a relatively new but burgeoning field with implications and applications in a wide variety of fields. Heritable post-translational epigenetic modifications (PTEMs) of chromatin can be induced by an ever-increasing list of biological factors, including those produced by bacteria. Of particular interest are the PTEMs induced by bacterial pathogens in host cells, in an attempt by the pathogen to promote survival and suppress host defence mechanisms. To date, a number of pharmacological agents have been used to reverse PTEMs, especially in cancer treatment. These
机译:表观遗传学代表着一个相对较新但正在迅速发展的领域,具有广泛的应用前景。染色质的可遗传翻译后表观遗传修饰(PTEM)可以通过越来越多的生物学因素(包括细菌产生的那些因素)来诱导。特别令人感兴趣的是由宿主细胞中的细菌病原体诱导的PTEM,病原体试图提高存活率并抑制宿主防御机制。迄今为止,许多药物已被用于逆转PTEM,特别是在癌症治疗中。这些

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