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首页> 外文期刊>Journal of clinical and experimental neuropsychology >Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals.
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Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals.

机译：脑外伤对HIV感染者认知功能和脑代谢产物的影响。

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摘要

We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms.
机译：我们探讨了创伤性脑损伤（TBI）历史对HIV（人类免疫缺陷病毒）相关的神经认知并发症的可能增强作用。将自我报告有明确TBI病史的HIV感染者与没有TBI病史的HIV患者进行比较。将各组等同于相关人口统计和与HIV相关的特征。 TBI小组证明了执行功能和工作记忆方面的明显缺陷。 TBI组的额叶灰质和基底神经节脑区域的N-乙酰天门冬氨酸，神经元完整性的公认标志物，明显较低。总之，这些结果表明，TBI对脑部的影响比仅对HIV的脑部影响更大。一种临床意义是，可能需要更密切地监测具有TBI病史的HIV患者，以增加与HIV相关的神经认知障碍体征或症状的风险。

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