Synthesis and biological evaluation of berberine derivatives bearing 4-aryl-1-piperazine moieties

Mistry Bhupendra; Keum Young-Soo; Kim Doo Hwan

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Synthesis and biological evaluation of berberine derivatives bearing 4-aryl-1-piperazine moieties

机译：带有4-芳基-1-哌嗪部分的小ber碱衍生物的合成及生物学评价

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Piperazine moieties with disubstituted N-aryl groups are linked to the isoquinoline alkaloid, berberine, through a pentyloxy side chain, replacing its 9-methoxyl group. The nine synthesised compounds are screened for antioxidant potency, in vitro anticancer activities against Hela and Caski cervical cancer cell lines and for cytotoxicity towards Malin Darby canine kidney cell lines. Several compounds demonstrate significant antioxidant potency and most of the compounds exhibit equipotent, or better, anticancer activity when compared to berberine.

机译：具有二取代的N-芳基的哌嗪部分通过戊氧基侧链连接到异喹啉生物碱小ber碱，取代了其9-甲氧基。筛选了九种合成的化合物的抗氧化剂效能，针对Hela和Caski宫颈癌细胞系的体外抗癌活性以及针对Malin Darby犬肾细胞系的细胞毒性。与小ber碱相比，几种化合物显示出显着的抗氧化剂功效，并且大多数化合物具有同等或更佳的抗癌活性。

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《Journal of chemical research: reviews and research papers from all branches of chemistry》 |2015年第8期|共5页
作者
Mistry Bhupendra; Keum Young-Soo; Kim Doo Hwan;
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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
berberine; piperazine; antioxidant; cervical cancer;

机译：小ber碱;哌嗪;抗氧化剂;宫颈癌;

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1. Synthesis and biological evaluation of berberine derivatives bearing 4-aryl-1-piperazine moieties [J] . Mistry Bhupendra, Keum Young-Soo, Kim Doo Hwan Journal of chemical research: reviews and research papers from all branches of chemistry . 2015,第8期

机译：带有4-芳基-1-哌嗪部分的小ber碱衍生物的合成及生物学评价
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Synthesis and biological evaluation of berberine derivatives bearing 4-aryl-1-piperazine moieties

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