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首页> 外文期刊>Journal of Clinical Ultrasound: JCU >Effects of intravitreal bevacizumab (Avastin) therapy on retrobulbar blood flow parameters in patients with neovascular age-related macular degeneration.
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Effects of intravitreal bevacizumab (Avastin) therapy on retrobulbar blood flow parameters in patients with neovascular age-related macular degeneration.

机译：玻璃体内贝伐单抗（Avastin）治疗对新生血管性年龄相关性黄斑变性患者球后血流参数的影响。

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摘要

BACKGROUND: To investigate the effects of intravitreal bevacizumab on retrobulbar circulation in patients with neovascular age-related macular degeneration (AMD). METHOD: Thirty patients with neovascular age-related macular degeneration were assessed prospectively by both color Doppler imaging and fundus fluorescein angiography. Spectral Doppler analysis allowed the measurement of the maximum velocity (Vmax) and minimum velocity (Vmin) of the central retinal vein (CRV), and peak systolic (PSV), end-diastolic (EDV) velocities of blood flows, and pulsatility index (PI) and resistance index (RI) values in the central retinal artery (CRA), nasal and temporal posterior ciliary arteries (NPCA, TPCA), and ophthalmic artery (OA). The t test for paired samples was used to compare retrobulbar blood flow values before and after intravitreal bevacizumab injection. RESULT: PSV and EDV of the NPCA and PSV of the TPCA were significantly decreased after intravitreal bevacizumab injection (p < 0.05). There was no statistically significant difference in the other parameters. CONCLUSION: Our results suggest that intravitreal bevacizumab therapy has a measurable effect on retrobulbar blood flow.
机译：背景：探讨玻璃体内贝伐单抗对新生血管性年龄相关性黄斑变性（AMD）患者球后循环的影响。方法：采用彩色多普勒显像和眼底荧光血管造影术对30例新血管性年龄相关性黄斑变性患者进行前瞻性评估。频谱多普勒分析允许测量视网膜中央静脉（CRV）的最大速度（Vmax）和最小速度（Vmin），血流的收缩期峰值（PSV），舒张末期（EDV）速度以及搏动指数（ PI）和视网膜中央动脉（CRA），鼻和颞后睫状动脉（NPCA，TPCA）和眼科动脉（OA）的阻力指数（RI）值。配对样品的t检验用于比较玻璃体内贝伐单抗注射前后的球后血流值。结果：玻璃体腔注射贝伐单抗后，NPCA的PSV和EDV以及TPCA的PSV显着降低（p <0.05）。其他参数没有统计学上的显着差异。结论：我们的结果表明玻璃体内贝伐单抗治疗对球后血流有可测量的影响。

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