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首页> 外文期刊>Journal of Clinical Ultrasound: JCU >Cerebrovascular reserve capacity in patients with hyperlipidemia.
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Cerebrovascular reserve capacity in patients with hyperlipidemia.

机译：高脂血症患者的脑血管储备能力。

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PURPOSE: Because recent data are conflicting, it is not certain whether hyperlipidemia is an independent risk factor for cerebrovascular diseases. Decreased cerebrovascular reserve capacity refers to the decreased ability of the cerebral arterioles to adapt in critical conditions and probably predicts a higher risk of stroke. The aim of this study was to compare cerebrovascular reserve capacity in hyperlipidemic patients and healthy controls using transcranial Doppler sonography. METHODS: Thirty-four hyperlipidemic patients and 21 healthy controls were examined. With transcranial Doppler sonography, the mean blood flow velocity in the middle cerebral artery was registered at rest and at 5, 10, 15, and 20 minutes after intravenous administration of 1,000 mg acetazolamide. Cerebrovascular reactivity and reserve capacity were calculated from mean blood flow velocities. Various laboratory measurements were also made and assessed for correlation with resting cerebral blood flow velocity and cerebrovascular reserve capacity. RESULTS: No significant differences could be observed between controls and hyperlipidemic patients in cerebrovascular reactivity or cerebrovascular reserve capacity. No correlation was found between various laboratory measurements and resting cerebral blood flow velocity or cerebrovascular reserve capacity. CONCLUSIONS: We could not demonstrate any differences in cerebrovascular reserve capacity between hyperlipidemic patients and healthy controls. Thus, the vasodilatory ability of the cerebral arterioles seems to remain unchanged in this patient group and is not correlated with the severity of hyperlipidemia. Copyright 2000 John Wiley & Sons, Inc.
机译：目的：由于最近的数据相互矛盾，因此尚不确定高脂血症是否是脑血管疾病的独立危险因素。脑血管储备能力的下降是指脑小动脉适应危急状况的能力下降，并且可能预示着中风的风险更高。这项研究的目的是使用经颅多普勒超声检查来比较高脂血症患者和健康对照者的脑血管储备能力。方法：检查了34例高脂血症患者和21例健康对照者。通过经颅多普勒超声检查，静注1000 mg乙酰唑胺后静息时以及在5、10、15和20分钟记录大脑中动脉的平均血流速度。根据平均血流速度计算脑血管反应性和储备能力。还进行了各种实验室测量，并评估了它们与静息脑血流速度和脑血管储备能力的相关性。结果：对照组和高脂血症患者在脑血管反应性或脑血管储备能力方面无显着差异。在各种实验室测量值与静息脑血流速度或脑血管储备能力之间未发现相关性。结论：我们无法证明高脂血症患者和健康对照者在脑血管储备能力上有任何差异。因此，在该患者组中，脑小动脉的血管舒张能力似乎保持不变，并且与高脂血症的严重程度无关。版权所有2000 John Wiley＆Sons，Inc.

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