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首页> 外文期刊>Journal of Clinical Ultrasound: JCU >Gender influence on left ventricular structure and function in metabolic syndrome. Are women at greater risk?
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Gender influence on left ventricular structure and function in metabolic syndrome. Are women at greater risk?

机译：性别对代谢综合征的左心室结构和功能的影响。妇女的风险更大吗？

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Purpose: The aim of this study was to investigate the influence of metabolic syndrome (MS) on left ventricular (LV) structure and function depending on gender. Methods: The study included 235 never-treated MS subjects and 138 controls. MS was defined as the presence of three or more National Cholesterol Education Program's Adult Treatment Panel III criteria. All the subjects underwent laboratory blood tests and complete two-dimensional, pulsed, and tissue Doppler echocardiography. Results: LV structure, diastolic function, and global function were significantly impaired in all MS subjects. Multivariate analysis of individual MS factors showed that increased blood pressure (BP) and impaired fasting glucose were independently associated with LV hypertrophy in women, whereas the only independent predictor in men was increased BP. The same analysis revealed that the combination of impaired glucose level, abdominal obesity, and dyslipidemia was associated with LV hypertrophy only in women. Higher BP, impaired fasting glucose, and triglycerides level were independently associated with LV diastolic dysfunction in women, whereas higher BP was the only independent predictor in men. The combination of increased BP, fasting glucose, and dyslipidemia was independently associated with LV diastolic dysfunction only in women. Conclusions: Different MS factors are responsible for LV remodeling in women and men. The metabolic sequence of MS is more important for LV remodeling in women.
机译：目的：本研究的目的是研究代谢综合症（MS）对左心室（LV）结构和功能的影响，具体取决于性别。方法：该研究包括235名从未接受过治疗的MS受试者和138名对照。 MS被定义为存在三个或更多个国家胆固醇教育计划的成人治疗小组III标准。所有受试者均接受了实验室血液检查，并完成了二维，脉冲和组织多普勒超声心动图检查。结果：所有MS受试者的LV结构，舒张功能和整体功能均显着受损。对各个MS因素的多变量分析显示，女性血压升高和空腹血糖受损与LV肥厚独立相关，而男性的唯一独立预测因素是BP升高。相同的分析表明，只有女性中葡萄糖水平降低，腹部肥胖和血脂异常的合并症与左室肥厚有关。较高的血压，空腹血糖受损和甘油三酸酯水平与女性左室舒张功能障碍独立相关，而较高的血压是男性的唯一独立预测因子。血压升高，空腹血糖和血脂异常的组合仅与女性左室舒张功能障碍有关。结论：不同的MS因素导致男女左室重塑。 MS的代谢序列对于女性的LV重塑更为重要。

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