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首页> 外文期刊>Clinical Biochemistry >Association of a salivary acetylcholinesterase with Alzheimer's disease and response to cholinesterase inhibitors.
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Association of a salivary acetylcholinesterase with Alzheimer's disease and response to cholinesterase inhibitors.

机译：唾液乙酰胆碱酯酶与阿尔茨海默氏病的关系以及对胆碱酯酶抑制剂的反应。

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摘要

OBJECTIVES: A decrease in cholinergic activity is a key event in the biochemistry of Alzheimer's disease (AD). The aim of the study was to investigate the expression levels of markers of cholinergic function in saliva, which is a readily accessible body fluid that can be obtained from subjects with minimal distress. DESIGN AND METHODS: Salivary samples were obtained from people with NINCDS-ARDRA "probable" Alzheimer's disease and age- and sex-matched controls. Salivary acetylcholinesterase enzyme (AChE) activity was determined colorometrically. RESULTS: Robust AChE catalytic activity was detected in the saliva samples that was stable for up to 6 h at room temperature following the provision of the salivary sample. The activity of the enzyme was significantly lower in people with AD than in age-matched controls. In addition, there were significant differences in activity between those who responded to acetylcholinesterase inhibitor (AChE-I) therapy and those who did not. CONCLUSIONS: Salivary enzyme activity may therefore prove to be a useful marker of central cholinergic activity.
机译：目的：胆碱能活性的降低是阿尔茨海默氏病（AD）生物化学中的关键事件。该研究的目的是研究唾液中胆碱能功能标志物的表达水平，唾液是一种容易获得的体液，可以从痛苦最小的受试者中获得。设计和方法：唾液样本是从患有NINCDS-ARDRA“可能”阿尔茨海默氏病以及年龄和性别相匹配的对照组的人获得的。唾液乙酰胆碱酯酶（AChE）活性通过比色法确定。结果：唾液样品中检测到了强大的AChE催化活性，在提供唾液样品后，该活性在室温下可稳定长达6小时。患有AD的人的酶活性明显低于年龄匹配的对照组。此外，对乙酰胆碱酯酶抑制剂（AChE-I）治疗有反应的人和对乙酰胆碱酯酶抑制剂（AChE-I）治疗无反应的人之间的活动存在显着差异。结论：唾液酶活性因此可能被证明是中枢胆碱能活性的有用标志。

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