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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Prognostic factors for post-operative seizure outcomes after cavernous malformation treatment.
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Prognostic factors for post-operative seizure outcomes after cavernous malformation treatment.

机译：海绵状畸形治疗后癫痫发作预后的预后因素。

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摘要

Although patients with cerebral cavernous malformations may remain asymptomatic, they often present with neurological symptoms of headache, hemorrhage and, most commonly, seizure. A review of articles published between 1985 and 2009 was performed to elucidate the prognostic factors which may predict post-operative seizure control. The following characteristics were found to consistently correlate with a more favorable post-operative seizure-free outcome: (i) extent of resection of the cavernous malformation and its surrounding hemosiderin rim; (ii) single or sporadic seizures compared to chronic epilepsy; (iii) illness duration less than 1 or 2 years; and (iv) size of cavernous malformation less than 1.5 cm. Radiosurgery may achieve post-operative seizure-free rates ranging from 25% to 64.3%, and may be an alternative to surgical resection for deep or eloquent cavernous malformations, or those in patients with co-morbidities. There was no clear association between post-operative seizures and either lesion location, age, or gender. Prognostic features of cavernous malformations should be utilized for both guidance of lesion treatment, and prediction of post-operative seizure outcomes.
机译：尽管患有脑海绵状畸形的患者可能没有症状，但他们经常表现出头痛，出血和最常见的癫痫发作的神经系统症状。回顾了1985年至2009年发表的文章，以阐明可能预测术后癫痫发作控制的预后因素。发现以下特征与更有利的术后无癫痫预后相一致：（i）切除海绵状畸形及其周围血铁蛋白边缘的程度; （ii）与慢性癫痫相比单发或偶发性癫痫发作; （iii）病程少于1或2年; （iv）海绵状畸形的大小小于1.5厘米。放射外科手术后的无癫痫发作率可达到25％至64.3％，并且可以替代深部或雄性海绵状畸形或合并症患者的手术切除。术后癫痫发作与病变部位，年龄或性别之间没有明确的关联。应当使用海绵状畸形的预后特征来指导病变治疗和预测术后癫痫发作的预后。

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