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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastoma
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Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastoma

机译：原发性口才性胶质母细胞瘤患者高血糖与术后功能丧失独立相关

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The poor prognosis for patients with glioblastoma (GB) heightens the importance of maintaining function throughout treatment. Hyperglycemia has been linked to poor neurological outcomes following stroke, traumatic brain and spinal cord injury. We hypothesized this may also be true following the resection of GB. We assessed associations with post-operative function with the goal of identifying modifiable factors in the peri-operative period with a particular focus on blood glucose levels. Independent associations with worse post-operative function included: patient age, pre-operative motor deficit, deep tumor location, post-operative motor deficit, and elevated mean peri-operative glucose. Interestingly, controlling for associated factors including dexamethasone dosing, patients with elevated peri-operative glucose levels were nearly twice as likely to have new post-operative neurological deficits. These results suggest, together with the broad literature supporting a role for hyperglycemia in neurological injury, that this may represent a modifiable factor in the peri-operative care of these patients.
机译：胶质母细胞瘤（GB）患者预后较差，因此在整个治疗过程中保持功能的重要性变得越来越重要。高血糖症与中风，脑外伤和脊髓损伤后不良的神经系统预后有关。我们假设GB切除后也可能如此。我们评估了与术后功能的关联，目的是在围手术期确定可改变的因素，尤其关注血糖水平。术后功能较差的独立关联包括：患者年龄，术前运动功能障碍，深部肿瘤位置，术后运动功能障碍和围手术期平均血糖升高。有趣的是，控制包括地塞米松剂量在内的相关因素，围手术期葡萄糖水平升高的患者发生新的术后神经功能缺损的可能性几乎是其两倍。这些结果表明，与支持高血糖在神经系统损伤中起作用的广泛文献一起，这可能代表了这些患者围手术期护理中的可调节因素。

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