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首页> 外文期刊>The world journal of biological psychiatry: the official journal of the World Federation of Societies of Biological Psychiatry >Interleukin-10 gene promoter polymorphism in patients with schizophrenia in a region of East Turkey.
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Interleukin-10 gene promoter polymorphism in patients with schizophrenia in a region of East Turkey.

机译：土耳其东部地区精神分裂症患者的白细胞介素10基因启动子多态性。

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摘要

Schizophrenia is one of the most severe psychiatric disorders, with a worldwide incidence of 1%. Immunological abnormalities have been found to be associated with schizophrenia for decades. Cytokines are key proteins involved in the immune system activation. Interleukin-10 (IL-10), an important immunoregulatory cytokine, is located on chromosome 1q31-32, a region previously reported to be linked to schizophrenia in genetic studies. In the present study it was aimed to examine the IL-10 gene promoter region's polymorphic variants in patients with schizophrenia in a population of the Elazig Region of East Anatolia, Turkey. Polymorphisms at position -1082, -819 and-592 in the IL-10 promoter region were determined in 171 Turkish patients who were diagnosed with schizophrenia, based on the DSM-IV, and 168 healthy controls, by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). We analyzed allele, genotype, and haplotype distributions using a case-control association study. Genotyping was performed by RFLP. Statistically significant differences were observed in both allelic and genotypic frequencies of the-592A/C polymorphism (Allele, P=0.034, OR = 1.26, 95% CI 1.02-1.56; Genotype, P=0.048), while the other two polymorphisms in distribution of the alleles and genotypes in patients with schizophrenia were not significantly different from those of controls (P>0.05). Our results show a significant increase of GTA homozygotes (the high IL-10-producing haplotype) in schizophrenic patients compared to control subjects (P=0.0001). These data suggest that the IL-10 gene promoter polymorphism may be one of the susceptibility factors to develop schizophrenia in the Turkish population, and apparently in all humans.
机译：精神分裂症是最严重的精神疾病之一，全世界范围内的发病率为1％。数十年来，已发现免疫异常与精神分裂症有关。细胞因子是参与免疫系统激活的关键蛋白。白细胞介素10（IL-10）是一种重要的免疫调节细胞因子，位于染色体1q31-32上，该区域先前在遗传学研究中被报告与精神分裂症有关。在本研究中，目的是检查土耳其东安纳托利亚Elazig地区人群中精神分裂症患者的IL-10基因启动子区多态性变异。根据DSM-IV，通过聚合酶链反应（PCR），确定了171位根据DSM-IV诊断为精神分裂症的土耳其患者和168位健康对照的IL-10启动子区域-1082，-819和-592位点的多态性-限制性片段长度多态性（RFLP）。我们使用病例对照关联研究分析了等位基因，基因型和单倍型分布。基因分型由RFLP进行。在-592A / C多态性的等位基因和基因型频率上均观察到统计学显着差异（等位基因，P = 0.034，OR = 1.26，95％CI 1.02-1.56;基因型，P = 0.048），而其他两个多态性分布精神分裂症患者的等位基因和基因型差异无统计学意义（P> 0.05）。我们的研究结果表明，与对照组相比，精神分裂症患者的GTA纯合子（产生高IL-10的单倍型）显着增加（P = 0.0001）。这些数据表明，IL-10基因启动子多态性可能是在土耳其人群中以及显然在所有人类中发展为精神分裂症的易感性因素之一。

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