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首页> 外文期刊>Journal of drugs in dermatology: JDD >Early treatment with nonsucrose intravenous immunoglobulin in a burn unit reduces toxic epidermal necrolysis mortality
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Early treatment with nonsucrose intravenous immunoglobulin in a burn unit reduces toxic epidermal necrolysis mortality

机译：在烧伤部位早期用非蔗糖静脉注射免疫球蛋白治疗可降低毒性表皮坏死症的死亡率

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Background: Intravenous immunoglobulin (IVIG) can be used to treat potentially deadly toxic epidermal necrolysis (TEN), milder Stevens Johnson Syndrome (SJS) and intermediate TEN/SJS overlap. Some formularies now deny IVIG for TEN based on the EuroSCAR TEN/SJS study that reported a nonsignificant trend toward increased mortality in 75 IVIG-treated TEN/SJS patients; of note the IVIG patients had more TEN and less SJS than patients in other treatment arms. EuroSCAR data on mortality among the 25 IVIG-treated TEN patients, use of nonsucrose IVIG, and admission to specialized settings such as burn units was not disclosed. The impact of treatment setting (specialized unit vs general ward) on IVIG efficacy has not previously been studied. Objective: To evaluate efficacy of treating TEN with early nonsucrose IVIG in a burn unit. Methods: Data were retrospectively collected from 13 IVIG-treated TEN patients admitted to a burn unit over a 6-year period. Results:We report 0% mortality among 13 IVIG-treated TEN patients. Mortality was significantly lower than predicted by SCORTEN. Mortality was also significantly lower than the EuroSCAR groups receiving IVIG (P<.005), supportive care (P<.018), and corticosteroids only (P<.046). Conclusion: TEN patients may benefit from early nonsucrose IVIG administered in burn units or other specialized settings.
机译：背景：静脉免疫球蛋白（IVIG）可用于治疗潜在致命的毒性表皮坏死症（TEN），史蒂文斯·约翰逊综合症（SJS）和中等程度的TEN / SJS重叠。根据EuroSCAR TEN / SJS研究，一些配方现在拒绝使用IVIG治疗TEN，该研究报告了75例接受IVIG治疗的TEN / SJS患者死亡率增加的趋势不显着。值得注意的是，IVIG患者比其他治疗组的患者有更多的TEN和更少的SJS。尚未披露有关25名接受IVIG治疗的TEN患者的死亡率，使用非蔗糖IVIG以及进入诸如烧伤病房等特殊环境的EuroSCAR数据。之前尚未研究过治疗设置（专门单位与普通病房）对IVIG疗效的影响。目的：评估早期非蔗糖IVIG在烧伤部位治疗TEN的疗效。方法：回顾性收集6年来经烧伤治疗的13例经IVIG治疗的TEN患者的数据。结果：我们报道13名接受IVIG治疗的TEN患者中死亡率为0％。死亡率显着低于SCORTEN的预测。死亡率也显着低于接受IVIG（P <.005），仅接受支持治疗（P <.018）和仅接受糖皮质激素（P <.046）的EuroSCAR组。结论：TEN患者可通过在烧伤病房或其他专门场所使用早期非蔗糖IVIG获益。

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