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首页> 外文期刊>Journal of drug delivery science and technology >Usefulness of a 3D skin construct in the detection of regenerative effects after previous SDS damage
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Usefulness of a 3D skin construct in the detection of regenerative effects after previous SDS damage

机译：3D皮肤构建体在检测先前SDS损伤后的再生效应中的有用性

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摘要

For permeation experiments or the assessment of irritating noxae artificial skin constructs (ASCs) are commonly used as in vitro models. They serve as a valuable tool when first data about formulations or new chemicals are obtained without performing animal testing. In this work ASCs are used as a predictive model for the evaluation of treatments that facilitate regeneration and wound healing after traumatization with sodium dodecyl sulfate solution. These ASCs comprised immortalized human keratinocytes that were air-exposed cultured on a fibroblast populated murine collagen gel. Using immortalized keratinocytes the model was easily accessible with standard cultivating techniques and media. Dexpanthenol was selected as a drug that is clinically used for wound healing. ASCs treated with a dexpanthenol supplement subsequent to traumatization with sodium dodecyl sulfate solution were investigated over a period of one week against controls. Dexpanthenol supplementation was shown to be superior to cultivation without supplementation; ASCs were also able to metabolize dexpanthenol. ASCs may therefore be suggested as being useful for this application.
机译：对于渗透实验或刺激性诺萨克病的评估，人造皮肤构建体（ASC）通常用作体外模型。在不进行动物测试的情况下获得有关配方或新化学物质的第一批数据时，它们可作为有价值的工具。在这项工作中，ASCs被用作预测模型，用于评估十二烷基硫酸钠溶液创伤后促进再生和伤口愈合的治疗方法。这些ASC包括永生化的人角质形成细胞，将其暴露在成纤维细胞中的鼠胶原蛋白凝胶上进行空气暴露培养。使用永生化的角质形成细胞，可以通过标准的培养技术和培养基轻松访问模型。选择右泛醇作为临床上用于伤口愈合的药物。在一周内针对对照研究了用十二烷基硫酸钠溶液创伤后用右旋泛醇补充剂治疗的ASC。事实证明，补充Dexpanthenol优于不补充栽培。 ASC也能够代谢右泛酚。因此，建议将ASC用于此应用程序。

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