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首页> 外文期刊>Journal of dermatological science >The CD226 Gly307Ser gene polymorphism is associated with severity of psoriasis.
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The CD226 Gly307Ser gene polymorphism is associated with severity of psoriasis.

机译：CD226 Gly307Ser基因多态性与牛皮癣的严重程度有关。

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Psoriasis is a chronic inflammatory T-cell mediated disease of the skin with a complex pathogenesis involving both genetic and environmental factors [1 ]. Several regions in the genome including the major histocompatibility complex (MHC) [2,3] have been reported to confer susceptibility to psoriasis risk; however, the genetic background of psoriasis is yet to be established. The Cluster of Differentiation 226 (CD226) molecule by interacting with its ligands, mediates a variety of cellular responses including innate and adaptive immunity [4,5]. A non-synonymous single nucleotide polymorphism (SNP) rs763361 (Gly307Ser) in the CD226 gene has recently been reported to be associated with several autoimmune-inflammatory diseases including type 1 diabetes and rheumatoid arthritis [6,7]. Following the notion that shared allelic variants confer susceptibility to several autoimmune disorders, the aim of the present study was to evaluate whether the Gly370Ser variant could also be implicated in the risk of plaque type psoriasis.
机译：银屑病是一种由皮肤炎性T细胞介导的慢性疾病，其发病机理复杂，涉及遗传和环境因素[1]。据报道，基因组中的几个区域，包括主要的组织相容性复合体（MHC）[2,3]，对银屑病风险具有敏感性。然而，牛皮癣的遗传背景尚未确定。分化簇226（CD226）分子通过与其配体相互作用，介导了多种细胞反应，包括先天免疫和适应性免疫[4,5]。 CD226基因中的一个非同义单核苷酸多态性（SNP）rs763361（Gly307Ser）最近被报道与几种自身免疫性炎症疾病有关，包括1型糖尿病和类风湿关节炎[6,7]。遵循共享等位基因变体赋予几种自身免疫性疾病易感性的观念之后，本研究的目的是评估Gly370Ser变体是否也可能与斑块型牛皮癣的风险有关。

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