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首页> 外文期刊>Journal of dermatological science >Mesenchymal-epithelial interactions in the skin: Aiming for site-specific tissue regeneration.
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Mesenchymal-epithelial interactions in the skin: Aiming for site-specific tissue regeneration.

机译：皮肤之间的间质-上皮相互作用：旨在特定部位的组织再生。

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Since trunk skin (or non-palmoplantar skin) is less durable under mechanical stress than sole skin (palm, plantar or palmoplantar skin), conventional trunk-derived skin grafts (including the trunk dermis) commonly result in erosion and ulceration when transplanted on to plantar wounds caused by various injuries including, diabetes mellitus or collagen diseases (including systemic sclerosis, polyarthritis nodosa and rheumatoid arthritis). However, trunk-derived epidermis can adopt a plantar phenotype, characterized by keratin 9 expression, hypopigmentation and thick suprabasal layers, through factors derived from plantar dermal fibroblasts in the wounds. Thus, intractable plantar wounds with exposed bones can be treated with the combination of bone marrow exposure, occlusive dressing and epidermal grafting. The higher expression of dickkopf 1 (DKK1), an inhibitor of canonical Wnt/beta-catenin signals, in the plantar dermis partly explains these phenomena. Thus, mesenchymal-epithelial interactions play important roles not only in embryogenesis (the embryonic development) but also in maintaining the homeostasis of adult tissue. The topographical (site-specific) interactions of growth factors and substances, including DKKs, fibroblast growth factors (FGFs) and transforming growth factor-beta (TGF-beta) family proteins including bone morphogenetic proteins (BMPs), may explain the site-specific differences in the skin in addition to the expression patterns of HOX genes and sonic hedgehogs (Shhs). We review the importance of dermal-epidermal interactions in tissue homeostasis and regeneration, especially in palms and soles.
机译：由于躯干皮肤（或非掌足皮肤）在机械应力下的耐用性不如单一皮肤（掌，足底或掌足皮肤）耐用，因此传统的躯干衍生皮肤移植物（包括躯干真皮）通常在移植到皮肤上时会导致糜烂和溃疡由各种损伤引起的足底伤口，包括糖尿病或胶原蛋白疾病（包括全身性硬化症，结节性多关节炎和类风湿性关节炎）。但是，躯干来源的表皮可以采用足底表型，其特征在于角膜9表达，色素沉着不足和基底上层厚，这是通过伤口中足底真皮成纤维细胞衍生的因子来实现的。因此，可以通过骨髓暴露，闭塞敷料和表皮移植的组合来治疗具有裸露的骨骼的顽固性足底伤口。足底真皮中典范Wnt /β-catenin信号抑制剂dickkopf 1（DKK1）的较高表达部分解释了这些现象。因此，间充质-上皮相互作用不仅在胚胎发生（胚胎发育）中而且在维持成年组织的稳态中都起重要作用。生长因子和物质（包括DKK，成纤维细胞生长因子（FGF）和转化生长因子β（TGF-beta）家族蛋白，包括骨形态发生蛋白（BMP））的地形（位点特异性）相互作用可以解释位点特异性除了HOX基因和声音刺猬（Shhs）的表达方式外，还存在皮肤差异。我们回顾了真皮-表皮相互作用在组织动态平衡和再生中的重要性，尤其是在手掌和脚掌中。

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