...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of dermatological science >Apoptosis coordinates with proliferation and differentiation during human hair follicle morphogenesis.
【24h】

Apoptosis coordinates with proliferation and differentiation during human hair follicle morphogenesis.

机译：在人毛囊形态发生过程中，细胞凋亡与增殖和分化相协调。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: : Apoptosis sculptures the most complicated skin appendage, feathers, out of epidermal layers by playing a variety of roles (1). Human hair follicle formation is different from feathers in growth direction and pattern formation of proliferative zone. OBJECTIVE: : To delineate the apoptotic events together with proliferation and differentiation in developing human hair follicle and emphasis on the mechanism and biological meaning of epidermal hair canal. METHODS: : We used TUNEL to examine apoptosis and Ki-67, involucrin, filaggrin immuno-localization to examine proliferation and differentiation. RESULTS: : In hair germs, apoptosis was diffuse in periderm, basal keratinocytes, and mesenchymal cells with high Ki-67 expression, but spared follicular germinative cells with low Ki-67 and high bcl-2 expression. In hair pegs, apoptosis was active in high Ki-67 expression area, like outer root sheath, hair follicle sheath, but spared dermal papilla with low Ki-67 and high bcl-2 expression. In bulbous pegs, apoptosis appeared in companion layer, precortical area, inner root sheath and outer root sheath, but spared bulge area with high bcl-2 expression. Apoptosis resulted in epidermal and subepidermal hair canal formation. Filaggrin and involucrin were expressed in the lining cells of hair canal. CD1a(+) cells were densely distributed alone the hair canal before its opening CONCLUSION: : During human hair follicle morphogenesis, apoptosis coordinates with proliferation to shape the growth zone, creates space to free the hair shaft from follicular wall, and directs a driving force on hair shaft extension. Apoptosis accompanies the terminal differentiation of epidermal hair canal. The bottom becomes interfollicular epidermis after roof shedding and hair exposure. Langerhans cells also populate in the hair canal before its opening. The biological meaning of epidermal hair canal is supposed to prepare the barrier when hair perturbing the intact of epidermis.
机译：背景：细胞凋亡通过发挥多种作用，从表皮层中雕刻出最复杂的皮肤附件，羽毛。人毛囊的形成与羽毛的生长方向和增生区的模式形成不同。目的：描述发展中的人类毛囊中的凋亡事件以及增殖和分化，并强调表皮毛细血管的机制和生物学意义。方法：：我们使用TUNEL检查细胞凋亡，并使用Ki-67，整合素，丝聚蛋白免疫定位检查增殖和分化。结果：在发芽中，凋亡在Ki-67高表达的周皮，基底角质形成细胞和间充质细胞中扩散，而剩余的Ki-67低而bcl-2表达高的卵泡生殖细胞则没有。在发夹中，凋亡在高Ki-67表达区域（如外根鞘，毛囊鞘）活跃，但保留了低Ki-67和高bcl-2表达的真皮乳头。在球形钉中，凋亡出现在伴生层，前皮质区，内根鞘和外根鞘中，但多余的凸起区域具有高bcl-2表达。凋亡导致表皮和表皮下的毛细血管形成。 Filaggrin和Involucrin在毛管的内衬细胞中表达。结论：在人类毛囊形态发生过程中，细胞凋亡与增殖协调形成生长区，创造空间使毛干脱离卵泡壁并引导驱动力在发干上。凋亡伴随表皮毛细血管的终末分化。屋顶脱落和头发暴露后，底部变成小泡间表皮。朗格汉斯细胞在张开前也存在于毛道中。当头发干扰表皮的完好性时，表皮毛管的生物学意义被认为是准备屏障。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号