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首页> 外文期刊>Journal of dermatological science >Dermal carotenoid level and kinetics after topical and systemic administration of antioxidants: enrichment strategies in a controlled in vivo study.
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Dermal carotenoid level and kinetics after topical and systemic administration of antioxidants: enrichment strategies in a controlled in vivo study.

机译：局部和全身施用抗氧化剂后的皮肤类胡萝卜素水平和动力学：在体内对照研究中的富集策略。

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BACKGROUND: High doses of sun-emitted UV-radiation induce reactive oxygen species (ROS) as major pro-oxidants thus inducing premature skin aging. The best prevention of the destructive action of free radicals in human skin is textile coverings, topical sunscreens and the development of a high antioxidative protective network. OBJECTIVE: The effects of topical, systemic and combined application of antioxidants (AO) were investigated on human skin in vivo. METHODS: Topical application of creams and systemic incorporation of tablets both containing AO was investigated in vivo by resonance Raman spectroscopy. RESULTS: Topical, systemic and combined AO-treatments induced a statistically significant increase of AO levels in human skin while placebo did not show any changes. The highest accumulation was induced by the combination of topical and systemic AO. Carotenoid-tablets combined with placebo-cream induced less carotenoid accumulation than carotenoid-tablets alone. Carotenoid levelling after the end of treatment lasted for around 2 weeks following the topical application of AOs, and up to 5 weeks after systemic administration, depending on the BMI of volunteers. CONCLUSION: Topically applied AO are stored in the SC for a short time only due to the rapid AO-depletion by desquamation, textile contact, washing and environmental stress. In contrast to topical application, the systemically applied carotenoids are stored in the body fat tissue and slowly released onto the skin surface with sweat and sebum. The combined topical and systemic application of AO represents an optimal form of protection of the AO-network.
机译：背景：高剂量的紫外线辐射会诱导活性氧（ROS）作为主要的促氧化剂，从而导致皮肤过早衰老。防止皮肤中自由基破坏的最佳方法是纺织品覆盖物，局部防晒霜和高抗氧化保护网络的发展。目的：研究抗氧化剂（AO）的局部，全身和联合应用对人体皮肤的体内作用。方法：通过共振拉曼光谱在体内研究了局部含有面霜的乳膏和片剂的全身性掺入。结果：局部，全身和联合AO治疗可引起人体皮肤AO水平的统计学显着增加，而安慰剂未显示任何变化。局部和全身AO的结合诱导了最高的积累。与单独的类胡萝卜素片剂相比，类胡萝卜素片剂与安慰剂乳膏相结合诱导的类胡萝卜素积聚较少。治疗结束后，类胡萝卜素的水平在局部应用AO后持续约2周，在全身给药后长达5周，具体取决于志愿者的BMI。结论：局部施用的AO只能在短时间内通过脱皮，接触纺织品，洗涤和环境压力迅速耗尽AO，从而在SC中短时间存储。与局部应用相反，全身应用的类胡萝卜素存储在体内脂肪组织中，并随着汗水和皮脂缓慢释放到皮肤表面。 AO的局部和系统组合应用代表了AO网络保护的最佳形式。

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