• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of dermatological science >Migration of human melanocytes into keratinocyte monolayers in vitro
【24h】

Migration of human melanocytes into keratinocyte monolayers in vitro

机译：人黑素细胞在体外向角质形成细胞单层的迁移

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The repigmentation of adult skin after wound healing, or loss of melanocytes (e.g. vitiligo), poses a particular and unique challenge to the invading population of melanocytes. The melanocytes, or their precursors, resident in adjacent skin or in nearby niches, must be activated to proliferate, and then negotiate their way through a tightly held epidermal barrier. The mechanisms whereby melanocytes negotiate their way through the epidermis to achieve this repigmentation have not been described in any detail and may occur trans-epidermally, and/or along the basement membrane and/or in the dermis. While there have been many studies on migratory cells during embryonic development and in particular physiological processes [1,2], these situations differ from the adult skin epidermal environment. To migrate through the tight spaces between keratinocytes, either junctions must be broken and spaces thus created, or alternatively, quite extreme cellular contortions would need to occur to allow the cell to move through the narrow paracellular spaces. Further knowledge of these processes will certainly contribute towards elucidating the mechanisms of repigmentation in pigmentary disorders.
机译：伤口愈合后成年皮肤的色素沉着或黑素细胞（例如白癜风）的丧失，对入侵的黑素细胞群提出了特殊而独特的挑战。驻留在相邻皮肤或附近小生境中的黑素细胞或其前体必须被激活以增殖，然后通过一个牢固保持的表皮屏障进行协商。黑色素细胞通过表皮协商其方式以实现该色素沉着的机制尚未详细描述，并且可能是经表皮和/或沿着基底膜和/或真皮发生的。尽管在胚胎发育过程中，特别是在生理过程中，有许多关于迁徙细胞的研究[1,2]，但这些情况与成年皮肤表皮环境不同。为了通过角质形成细胞之间的紧密空间迁移，必须断开任何连接并由此形成空间，或者，将需要发生相当极端的细胞扭曲，以使细胞能够通过狭窄的旁细胞空间。对这些过程的进一步了解无疑将有助于阐明色素性疾病中的色素沉着机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号