Five-coordinated oxovanadium(IV) complexes derived from amino acids and ciprofloxacin: synthesis, spectral, antimicrobial, and DNA interaction approach.

Patel MN; Patel SH; Chhasatia MR; Parmar PA

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Five-coordinated oxovanadium(IV) complexes derived from amino acids and ciprofloxacin: synthesis, spectral, antimicrobial, and DNA interaction approach.

机译：由氨基酸和环丙沙星衍生的五配位氧钒（IV）配合物：合成，光谱，抗微生物和DNA相互作用方法。

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Five-coordinated oxovanadium(IV) complexes with ciprofloxacin and various uninegative bidentate amino acids have been prepared. The structure of complexes has been investigated using spectral, physicochemical, mass spectroscopy, and elemental analyses. The antimicrobial activities (MIC) of the complexes, ligands, metal salt, and some standard drugs have been evaluated using the doubling dilution technique against Staphylococcus aureus, Bacillus subtilis, Serratia marcescens (gram-positive), and Pseudomonas aeruginosa, and Escherichia coli (gram-negative) bacteria. The result shows the significant increase in the antibacterial activity of the ligand, metal, and ciprofloxacin on complexation. The interaction of the complexes with pBR322 DNA has been investigated using spectroscopic, gel electrophoresis, and viscometric techniques. This shows that the complexes can bind to pBR322 DNA by the intercalative mode. The superoxide dismutase-like activity of the complexes has been determined.

机译：已经制备了具有环丙沙星和各种单负性双齿氨基酸的五配位氧钒（IV）配合物。配合物的结构已使用光谱，理化，质谱和元素分析进行了研究。使用双倍稀释技术评估了复合物，配体，金属盐和一些标准药物的抗微生物活性（MIC），其对金黄色葡萄球菌，枯草芽孢杆菌，粘质沙雷氏菌（革兰氏阳性），铜绿假单胞菌和大肠杆菌（革兰氏阴性）细菌。结果表明配体，金属和环丙沙星对复合物的抗菌活性显着提高。使用光谱，凝胶电泳和粘度技术研究了复合物与pBR322 DNA的相互作用。这表明复合物可以通过插入模式与pBR322 DNA结合。已经确定了复合物的超氧化物歧化酶样活性。

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《Bioorganic and Medicinal Chemistry Letters》 |2008年第24期|共7页
作者
Patel MN; Patel SH; Chhasatia MR; Parmar PA;
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正文语种 eng
中图分类药学;生物化学;
关键词
DNA; Ciprofloxacin; Roman Numeral IV; Five; Amino Acids; 环丙沙星; 氨基酸类;

机译：DNA;Ciprofloxacin;Roman Numeral IV;Five;Amino Acids;环丙沙星;氨基酸类;

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1. Five-coordinated oxovanadium(IV) complexes derived from amino acids and ciprofloxacin: synthesis, spectral, antimicrobial, and DNA interaction approach. [J] . Patel MN, Patel SH, Chhasatia MR, Bioorganic and Medicinal Chemistry Letters . 2008,第24期

机译：由氨基酸和环丙沙星衍生的五配位氧钒（IV）配合物：合成，光谱，抗微生物和DNA相互作用方法。
2. Synthesis, spectral characterization and antimicrobial studies of nano-sized oxovanadium(IV) complexes with Schiff bases derived from 5-(phenyl/substituted phenyl)-2-hydrazino-1,3,4-thiadiazole and indoline-2,3-dione [J] . M.K. Sahani, U. Yadava, O.P. Pandey, Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy . 2014,第Null期

机译：具有5-（苯基/取代苯基）-2-肼基-1,3,4-噻二唑和二氢吲哚-2,3-二酮的席夫碱的纳米氧化钒（IV）配合物的合成，光谱表征和抗菌研究
3. Synthesis, spectral, thermal and crystallographic investigations on oxovanadium(IV) and manganese(III) complexes derived from heterocyclic β-diketone and 2-amino ethanol [J] . B. T. Thaker, Kiran R. Surati, Shantilal Oswal, Structural Chemistry . 2007,第3期

机译：杂环β-二酮和2-氨基乙醇衍生的氧钒（IV）和锰（III）配合物的合成，光谱，热学和晶体学研究
4. Hyper branched poly(amino acids):synthesis,structure and interaction with DNA [C] . Guennady P.Vlasov, Irina I.Tarasenko, Svetlana V.Valueva International Peptide Symposium;European Peptide Symposium . 2005

机译：超分支聚（氨基酸）：合成，结构和与DNA相互作用
5. Interactions of dinuclear transition metal complexes with amino acids, nucleotides, and DNA. [D] . Hess, Jennifer Simone. 1998

机译：双核过渡金属络合物与氨基酸，核苷酸和DNA的相互作用。
6. Synthesis Spectral and In Vitro Antibacterial Studies of Organosilicon(IV) Complexes with Schiff Bases Derived from Amino Acids [O] . Har Lal Singh, Jangbhadur Singh, A. Mukherjee 2013

机译：具有氨基酸席夫碱的有机硅（IV）配合物的合成光谱和体外抗菌研究
7. Metal based pharmacologically active agents: Synthesis, structural elucidation, DNA interaction, in vitro antimicrobial and in vitro cytotoxic screening of copper(II) and zinc(II) complexes derived from amino acid based pyrazolone derivatives [O] . Raman N., Jeyamurugan R., Sudharsan S., 2013

机译：金属基药理活性剂：衍生自氨基酸的吡唑酮衍生物的铜（II）和锌（II）配合物的合成，结构阐明，DNA相互作用，体外抗菌和体外细胞毒性筛选

Five-coordinated oxovanadium(IV) complexes derived from amino acids and ciprofloxacin: synthesis, spectral, antimicrobial, and DNA interaction approach.

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