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首页> 外文期刊>Journal of experimental & clinical cancer research : >Evaluation of DNA content in preneoplastic changes of mouse urinary bladder induced by N-butyl-N-(4-hydroxybutyl) nitrosamine.
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Evaluation of DNA content in preneoplastic changes of mouse urinary bladder induced by N-butyl-N-(4-hydroxybutyl) nitrosamine.

机译：N-丁基-N-（4-羟丁基）亚硝胺诱导的小鼠膀胱癌前变化中DNA含量的评估。

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Using image cytometry analysis we analysed the deoxyribonucleic acid content of preneoplastic lesions induced in C3H/He female mice. Female mice (n = 30) were given 0.05% BBN in their drinking water for 4, 8 and 12 weeks, and were then euthanized. At the 4th week 90% hyperplasias, 90% dysplasias and 10% papillary tumours developed selectively in the bladder, after 8 weeks mice developed 80% hyperplasias and 80% dysplasias and 12 weeks we identified 70% hyperplasias, 70% dysplasias, 10% papillary tumours and 20% squamous metaplasia. Among the ones who developed simple hyperplasia, 58.3% were diploid and 41.7% were aneuploid. In the dysplasia lesions 29.2% were diploid and 70.8% were aneuploid (p = 0.041). All papillary tumours were aneuploid and all epidermoid metaplasias were diploid. These results suggest that aneuploidization, DNA content alteration of preneoplastic lesions, might be considered as a prognostic factor.
机译：使用图像流式细胞仪分析，我们分析了C3H / He雌性小鼠诱发的肿瘤前病变的脱氧核糖核酸含量。对雌性小鼠（n = 30）在其饮用水中给予0.05％BBN，持续4、8和12周，然后实施安乐死。在第4周，90％的增生，90％的不典型增生和10％的乳头状肿瘤在膀胱中选择性发展，在8周后，小鼠出现80％的增生和80％的不典型增生，在第12周，我们发现70％的增生，70％的不典型增生，10％的乳头状增生肿瘤和20％鳞状上皮化生。在发生单纯性增生的人中，二倍体占58.3％，非整倍体占41.7％。在不典型增生中，病变的二倍体为29.2％，非整倍体为70.8％（p = 0.041）。所有乳头状瘤均为非整倍体，所有表皮样化生为二倍体。这些结果表明，非整倍体化，肿瘤前病变的DNA含量改变可能被认为是预后因素。

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