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首页> 外文期刊>Journal of experimental & clinical cancer research : >MR spectroscopy of prostate cancer. Initial clinical experience.
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MR spectroscopy of prostate cancer. Initial clinical experience.

机译：前列腺癌的MR光谱。初步临床经验。

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摘要

Aim of the study was to evaluate the effectiveness of proton MR Spectroscopic (MRS) imaging in the detection and localization of prostate cancer, prospectively compared with histopathologic findings. Magnetic Resonance (MR) and MRS imaging were performed in 65 patients with high levels of prostate-specific antigen (PSA) and suspicious areas at the transrectal ultrasound (TRUS). At MR areas of interest were reported as normal, equivocal or suspicious. At MRS imaging, cancer was diagnosed as possible above mean normal peripheral zone values or as "definite" if the ratio exceeded 3 SDs. All patients underwent a TRUS 10-core biopsy within 30 days of the imaging study. MR alone showed sensitivity, specificity, positive predictive values, negative predictive values and accuracy for detection of prostate cancer of 85%, 76%, 53%, 91% and 65%, respectively, whereas MRS alone showed 89%, 77%, 78%, 69% and 83%, respectively. These values were 71%, 90%, 89%, 74% and 80% when the prostate was evaluated combining MRand MRS. The addition of MRS to the MR imaging provides a higher specificity in tumour detection and can be recommended as a problem-solving modality for patients with elevated PSA levels and suspicious TRUS before biopsy.
机译：这项研究的目的是评估质子磁共振波谱（MRS）成像在前列腺癌的检测和定位中的有效性，并与组织病理学结果进行前瞻性比较。在65例具有高水平前列腺特异性抗原（PSA）和经直肠超声（TRUS）可疑区域的患者中进行了磁共振（MR）和MRS成像。在MR，感兴趣的区域被报告为正常，模棱两可或可疑的区域。在MRS成像中，如果比率超过3 SD，则诊断出癌症的可能性可能高于平均正常外周区值或“确定”。在影像学研究的30天内，所有患者均接受了TRUS 10核活检。单独的MR显示检测前列腺癌的敏感性，特异性，阳性预测值，阴性预测值和准确性分别为85％，76％，53％，91％和65％，而仅MRS则显示89％，77％，78 ％，69％和83％。当结合MR和MRS评估前列腺时，这些值为71％，90％，89％，74％和80％。在MR成像中增加MRS可在肿瘤检测中提供更高的特异性，可建议将其作为PSA水平升高和活检前可疑TRUS患者的解决方法。

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