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首页> 外文期刊>Journal of experimental & clinical cancer research : >Atypical thyroid nodules express both HBME-1 and Galectin-3, two phenotypic markers of papillary thyroid carcinoma.
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Atypical thyroid nodules express both HBME-1 and Galectin-3, two phenotypic markers of papillary thyroid carcinoma.

机译：非典型甲状腺结节同时表达HBME-1和Galectin-3，这是甲状腺乳头状癌的两个表型标志。

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摘要

Ninety-six thyroid lesions were immunohistochemically evaluated for HBME-1 and Galectin-3 expression including nodules with cytological atypia, the latter defined as nuclear features suggestive but not diagnostic of papillary thyroid carcinoma. Thirty nodules with cytological atypia, 49 papillary thyroid carcinomas (PTCs), 4 follicular carcinomas and 13 oxyphilic tumors were examined. Forty-one of the 49 PTCs, 16 atypical thyroid nodules and 3 non-malignant oxyphilic tumors exhibited a combined expression of HBME-1 and Galectin-3. In 6 of the sixteen atypical thyroid nodules the immunoreactivity for both markers was strong and diffuse, simulating the pattern observed in PTC. We conclude that thyroid nodules with cytological atypia and strong/diffuse positivity for both HBME-1 and Galectin-3, two well recognized markers of PTC, represent a starting phenotypic change towards PTC, for which a benign or borderline counterpart has not yet been defined. The expression of HBME-1 and Galectin-3 in some thyroidnodules is related to the presence of cytological atypia suggestive but not diagnostic of PTC. The phenotypic similarity between this subset of thyroid nodules with cytological atypia and PTC is also confirmed by our data according to which Galectin-3 and HBME-1 have been found to be highly sensitive for PTC.
机译：免疫组化评估了96个甲状腺病变的HBME-1和Galectin-3表达，包括具有细胞学异型的结节，后者被定义为具有核特征，但不能诊断为甲状腺乳头状癌。检查了30例具有细胞学异型的结节，49例甲状腺乳头状癌（PTC），4例滤泡癌和13例嗜氧性肿瘤。 49个PTC中的41个，16个非典型甲状腺结节和3个非恶性嗜氧性肿瘤表现出HBME-1和Galectin-3的联合表达。在16个非典型甲状腺结节中的6个中，两种标记物的免疫反应性均强而弥散，模拟了PTC中观察到的模式。我们得出结论，甲状腺结节具有细胞学上的异型性，并且对于HBME-1和Galectin-3（PTC的两个公认的标志物）具有强/弥散阳性，代表了PTC的初始表型改变，尚未确定其良性或临界性对应物。某些甲状腺结节中HBME-1和Galectin-3的表达与提示PTC的细胞学异型有关，但与PTC的诊断无关。我们的数据也证实了甲状腺小结节与细胞学异型的亚型和PTC之间的表型相似性，根据该数据，已发现Galectin-3和HBME-1对PTC高度敏感。

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