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首页> 外文期刊>Journal of experimental & clinical cancer research : >The pilot trial of the prevention of the increase in electrical taste thresholds by zinc containing fluid infusion during chemotherapy to treat primary lung cancer.
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The pilot trial of the prevention of the increase in electrical taste thresholds by zinc containing fluid infusion during chemotherapy to treat primary lung cancer.

机译：在治疗原发性肺癌的化学疗法中，通过含锌液体输注预防电气味阈值升高的试验性试验。

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摘要

It is well known that there are various adverse effects during chemotherapy for cancer treatment. A taste disorder is also seen in 35-70% of patients. It has been reported that a zinc deficiency is associated with the development of these alterations in taste sensation. The purpose of this pilot study was to determine whether the zinc including infusion had the effect on taste disorder in patients with lung cancer. Taste disorder was evaluated as the increase in electrical taste thresholds using an electrogustometer. The plasma zinc concentration was also measured. Although there was no significant correlation, the increase in taste thresholds was detected in many patients who had a low zinc concentration even before receiving chemotherapy. Moreover, after 2 weeks of chemotherapy, almost all patients who did not have a zinc containing infusion showed development of taste disorder (5/5, 100% at chorda tympani area; 4/5, 80% at glossopharyngeal area), whereas no development of taste disorder was observedin those patients receiving a zinc containing infusion. These results suggest the possibility that the administration of zinc during chemotherapy could be a useful supportive therapy for preventing taste disorder and to help maintain a better quality of life.
机译：众所周知，在癌症治疗的化学疗法中有各种不良反应。在35-70％的患者中也发现了味觉障碍。据报道，锌缺乏与这些味觉改变的发展有关。这项初步研究的目的是确定含锌的输液是否对肺癌患者的味觉障碍有影响。使用电测功计将味觉障碍评估为电子味觉阈值的增加。还测量了血浆锌浓度。尽管两者之间没有显着相关性，但许多锌浓度低的患者甚至在接受化疗之前就发现了味觉阈值的升高。此外，在化疗2周后，几乎所有未接受含锌输液的患者均出现味觉障碍的发展（5/5，在鼓膜鼓室区域为100％;在舌咽部区域为4 / 5，80％），而没有发展在接受含锌输液的那些患者中观察到味觉障碍。这些结果表明，在化疗期间施用锌可能是预防味觉障碍和帮助维持更好生活质量的有用支持疗法。

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