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首页> 外文期刊>Journal of experimental & clinical cancer research : >Clinicopathologic significance of cyclin A expression in colorectal carcinoma.
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Clinicopathologic significance of cyclin A expression in colorectal carcinoma.

机译：大肠癌中cyclin A表达的临床病理学意义。

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The clinical significance of cyclin A expression, which has been known to act in the mitotic phase of the cell cycle, as an indicator of malignant potential in human tumors, has been suggested. The aim of this study was to elucidate the significance of immunohistochemical expression of cyclin A in colorectal carcinomas based on a larger study population. Immunohistochemical staining for cyclin A was performed for 167 colorectal carcinomas and the correlation between cyclin A expression and the clinicopathological characteristics was analyzed. One hundred and two carcinomas (61.1%) had cyclin A expression and the other 65 (38.9%) did not. The mean size of the tumors with cyclin A expression was significantly larger than that of tumors without cyclin A expression (p = 0.012). Survival in patients with cyclin A-expressing carcinomas was significantly worse than that in patients with carcinomas without cyclin A expression (p = 0.004). Cyclin A expression (p = 0.030), as well as lymph node metastasis (p = 0.007) and Dukes' stage of the tumors (p < 0.0001) were found to be factors independently associated with unfavorable prognosis in patients with colorectal carcinoma. Our results demonstrated that immunohistochemical expression of cyclin A is an independent prognostic indicator in patients with colorectal carcinoma.
机译：已经提出了细胞周期蛋白A表达的临床意义，已知该蛋白在细胞周期的有丝分裂期起作用，作为人肿瘤中恶性潜能的指标。这项研究的目的是阐明基于大量研究人群的大肠癌中cyclin A免疫组化表达的重要性。对167例结直肠癌进行了cyclin A的免疫组织化学染色，分析了cyclin A的表达与临床病理特征的相关性。一百零二种癌（61.1％）表达细胞周期蛋白A，而另外六十五种癌（38.9％）则没有。具有细胞周期蛋白A表达的肿瘤的平均大小明显大于没有细胞周期蛋白A表达的肿瘤的平均大小（p = 0.012）。表达细胞周期蛋白A的患者的生存率显着低于没有细胞周期蛋白A表达的患者（p = 0.004）。 Cyclin A的表达（p = 0.030），淋巴结转移（p = 0.007）和肿瘤的Dukes分期（p <0.0001）被发现与大肠癌患者预后不良相关。我们的结果表明，cyclin A的免疫组织化学表达是结直肠癌患者的独立预后指标。

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