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Towards a genetic architecture of cryptic genetic variation and genetic assimilation: the contribution of K. G. Bateman

机译:建立隐秘遗传变异和遗传同化的遗传结构:K. G. Bateman的贡献

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摘要

Clearly spurred on by Waddington, Bateman (1959) continued the work on the crossveinless phenocopy in Dro-sophila melanogaster and helped to establish it as a model system in quantitative genetics for threshold traits. In this commentary, I will discuss the context of this work examining the genetic architecture of the crossveinless phenocopy both within the light of current studies of evolutionary genetics, and modern evolutionary-developmental biology. Far from being a historical curiosity, it appears that this phenotype may be a relevant and powerful model system for current studies of cryptic genetic variation and possibly for examining allelic architecture of complex diseases. I will discuss what future research directions will allow for this possibility.
机译:沃丁顿(Waddington)明显地鼓励他,巴特曼(Bateman,1959年)继续进行了果蝇(Dro-sophila melanogaster)无静脉表型的研究,并帮助将其建立为阈值性状的定量遗传学模型系统。在这篇评论中,我将讨论这项工作的背景,既要根据当前的进化遗传学研究,又要结合现代进化-发展生物学,研究无静脉表型的遗传结构。显然,这种表型可能不是对历史的好奇心,而是对于当前隐性遗传变异研究以及对复杂疾病等位基因结构的研究而言,可能是一个相关且强大的模型系统。我将讨论未来的研究方向将允许这种可能性。

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